Evidence map›Paper›PMID 33929697›Full record

ArticleBiochemical genetics2021

Prostaglandin Endoperoxide H Synthase-2 (PGHS-2) Variants and Risk of Obesity and Microvascular Dysfunction Among Tunisians: Relevance of rs5277 (306G/C) and rs5275 (8473T/C) Genetic Markers.

Ahlem Touir, Soumaya Boumiza, Hela Ben Nasr, Sarra Bchir, Zouhair Tabka, Xavier Norel, Karim Chahed

Abstract read
PubMed Publisher
In one paragraph

Article in Biochemical genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Ahlem TouirInstitut Supérieur de Biotechnologie de Monastir, Université de Monastir, Avenue Tahar Hadded, BP 74, 5000, Monastir, Tunisia. ahlemtouir1503@gmail.com.ORCID http://orcid.org/0000-0003-1819-4029
Soumaya BoumizaLaboratoire de Recherche LR19ES09, Physiologie de L'Exercice Et Physiopathologie: de L'Intégré Au Moléculaire "Biologie, Médecine Et Santé, Université de Sousse, Sousse, Tunisia.
Hela Ben NasrLaboratoire de Recherche LR19ES09, Physiologie de L'Exercice Et Physiopathologie: de L'Intégré Au Moléculaire "Biologie, Médecine Et Santé, Université de Sousse, Sousse, Tunisia.
Sarra BchirLaboratoire de Recherche LR19ES09, Physiologie de L'Exercice Et Physiopathologie: de L'Intégré Au Moléculaire "Biologie, Médecine Et Santé, Université de Sousse, Sousse, Tunisia.
Zouhair TabkaLaboratoire de Recherche LR19ES09, Physiologie de L'Exercice Et Physiopathologie: de L'Intégré Au Moléculaire "Biologie, Médecine Et Santé, Université de Sousse, Sousse, Tunisia.
Xavier NorelINSERM U1148, Laboratory for Vascular Translational Science, CHU X. Bichat, 46 rue Huchard, 75018, Paris, France.
Karim ChahedLaboratoire de Recherche LR19ES09, Physiologie de L'Exercice Et Physiopathologie: de L'Intégré Au Moléculaire "Biologie, Médecine Et Santé, Université de Sousse, Sousse, Tunisia.
University of Sousse · TNInserm · FRUniversity of Monastir · TNUniversity of Sfax · TN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of this study was to determine the impact of six PGHS-2 genetic variants on obesity development and microvascular dysfunction. The study included 305 Tunisian subjects (186 normal weights, 35 overweights and 84 obeses). PCR analyses were used for allelic discrimination between polymorphisms. Prostaglandin (PGE2, PGI2), leptin, and matrix metalloproteinase (MMP1, 2, 3, 9) levels were evaluated by ELISA. Fatty acid composition was performed by gas chromatography-mass spectrometry. Our results revealed that subjects carrying the PGHS-2 306CC (rs5277) and 8473CC (rs5275) genotypes present higher anthropometric values compared to wild-type genotypes (306GG, BMI (Kg/m

Indexed as

DinoprostoneObesityCyclooxygenase 2Genetic MarkersHumansProstaglandin H2Cyclooxygenase 2DinoprostoneGenetic MarkersProstaglandin H2InflammationMicrovascular reactivityObesityPGHS-2Polymorphism

Identifiers

PMID33929697
OpenAlexW3158238048

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.