Evidence map›Paper›PMID 33929320›Full record

ArticleeLife2021

The transcription factor Rreb1 regulates epithelial architecture, invasiveness, and vasculogenesis in early mouse embryos.

Sophie M Morgani, Jie Su, Jennifer Nichols, Joan Massagué, Anna-Katerina Hadjantonakis

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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  7. TGF-β in developmental and fibrogenic EMTs.Seminars in cancer biology · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Sophie M MorganiDevelopmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States.ORCID 0000-0002-4290-1080
Jie SuCancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States.ORCID 0000-0002-3071-7139
Jennifer NicholsWellcome Trust-Medical Research Council Centre for Stem Cell Research, University of Cambridge, Jeffrey Cheah Biomedical Centre Cambridge Biomedical Campus, Cambridge, United Kingdom.ORCID 0000-0002-8650-1388
Joan MassaguéCancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States.ORCID 0000-0001-9324-8408
Anna-Katerina HadjantonakisDevelopmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States.ORCID 0000-0002-7580-5124
Memorial Sloan Kettering Cancer Center · USWellcome/MRC Cambridge Stem Cell Institute · GB

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
The TGF Beta Signaling Pathway in Development and CancerR35CA252978 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI JOAN MASSAGUE · 2020 to 2026
$7.3M
Mechanisms driving cell fate specification and morphogenesis in the blastocystR01HD094868 · NICHD · SLOAN-KETTERING INST CAN RESEARCH · PI ANNA-KATERINA HADJANTONAKIS · 2018 to 2026
$4.2M
Morphogenesis of mammalian gut endodermR01DK084391 · NIDDK · SLOAN-KETTERING INST CAN RESEARCH · PI HADJANTONAKIS, ANNA-KATERINA · 2009 to 2018
$4.1M
Phenotyping Early Embryonic Lethal Knockout Mice to Identify Essential Genes with Previously Uncharacterized Roles in Pre-implantation Development, Gastrulation, Turning, and PlacentationR01HD086478 · NICHD · SLOAN-KETTERING INST CAN RESEARCH · PI HADJANTONAKIS, ANNA-KATERINA · 2016 to 2020
$3.4M
The gut endoderm: origin, formation and fateR01DK127821 · NIDDK · SLOAN-KETTERING INST CAN RESEARCH · PI ANNA-KATERINA HADJANTONAKIS · 2021 to 2026
$3.4M
TGFB-SMAD Signaling in Stem Cell Differentiation and Tumor SuppressionR01CA034610 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MASSAGUE, JOAN · 1985 to 2019
$2.3M
CXCL5/CXCR2 axis as a therapeutic vulnerability of breast cancer metastasis to boneR01CA252878 · NCI · UNIVERSITY OF NOTRE DAME · PI LITTLEPAGE, LAURIE E. · 2021 to 2025
$1.8M
Medical Research Council MC_PC_17230NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA034610NCI NIH HHS R01 CA252878NCI NIH HHS R35 CA252978NICHD NIH HHS R01 HD086478NICHD NIH HHS R01 HD094868NIDDK NIH HHS R01 DK084391NIDDK NIH HHS R01 DK127821Wellcome TrustWellcome Trust 110151/Z/15/Z
6 · The paper itself

Abstract

Ras-responsive element-binding protein 1 (Rreb1) is a zinc-finger transcription factor acting downstream of RAS signaling.

Indexed as

Neovascularization, PhysiologicActinsAdherens JunctionsAnimalsBlood VesselsDNA-Binding ProteinsEmbryonic DevelopmentEpithelial CellsMiceMice, Inbred C57BLMice, KnockoutTranscription FactorsActinsDNA-Binding ProteinsRreb1 protein, mouseTranscription Factorscardiovascular developmentcell biologydevelopmentdevelopmental biologyepitheliumgastrulationinvasionmouseRreb1

Identifiers

PMID33929320
PMCPMC8131102
OpenAlexW3157566358

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.