Evidence map›Paper›PMID 33929319›Full record

ArticleeLife2021

IL-33 promotes innate lymphoid cell-dependent IFN-γ production required for innate immunity to

Joseph T Clark, David A Christian, Jodi A Gullicksrud, Joseph A Perry, Jeongho Park, Maxime Jacquet, James C Tarrant, Enrico Radaelli, Jonathan Silver, Christopher A Hunter

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Innovation through imitation: IL-33 decoys show promise in pulmonary fibrosis.The Journal of pharmacology and experimental therapeutics · 2025
    Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. ILCs-Crucial Players in Enteric Infectious Diseases.International journal of molecular sciences · 2022
    Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Nuclear IL-33 as a growth and survival agent within basal cells.The Journal of clinical investigation · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Joseph T ClarkDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, United States.ORCID 0000-0001-7764-6000
David A ChristianDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, United States.
Jodi A GullicksrudDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, United States.
Joseph A PerryDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, United States.
Jeongho ParkDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, United States.
Maxime JacquetDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, United States.
James C TarrantDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, United States.
Enrico RadaelliDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, United States.
Jonathan SilverDepartment of Respiratory Inflammation and Autoimmunity, AstraZeneca, Gaithersburg, United States.
Christopher A HunterDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, United States.ORCID 0000-0003-3092-1428
University of Pennsylvania · USAstraZeneca (United States) · USKangwon National University · KRUniversity of Basel · CH

Funding

IMMUNOBIOLOGY OF NORMAL AND NEOPLASTIC LYMPHOCYTEST32CA009140 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Malay Haldar, WARREN S PEAR · 1985 to 2026
$16.1M
PARASITOLOGY: MODERN APPROACHEST32AI007532 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HERBERT, DE'BROSKI R · 1998 to 2022
$5.0M
Impact of early T-bet on CD8 T cell effector responsesR01AI125563 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HUNTER, CHRISTOPHER A · 2016 to 2020
$2.0M
Myeloid derived IL-33 controls Treg responses during parasite infectionR01AI164715 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HERBERT, DE'BROSKI R · 2021 to 2024
$1.6M
NCI NIH HHS T32 CA009140NIAID NIH HHS R01 AI125563NIAID NIH HHS R01 AI164715NIAID NIH HHS T32 AI007532
6 · The paper itself

Abstract

IL-33 is an alarmin required for resistance to the parasite

Indexed as

AnimalsFemaleHumansImmunity, InnateInterferon-gammaInterleukin-33LymphocytesMaleMiceMice, Inbred C57BLMice, KnockoutToxoplasmaToxoplasmosisInterferon-gammaInterleukin-33IL-1 familyIL-33immunologyinfectious diseaseinflammationinnate lymphoid cellsmicrobiologymouseToxoplasma gondii

Identifiers

PMID33929319
PMCPMC8121546
OpenAlexW3157199935

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.