Evidence map›Paper›PMID 33929265›Full record

ArticleRadiology. Imaging cancer2021

Segmentation of the Prostate Transition Zone and Peripheral Zone on MR Images with Deep Learning.

Michelle Bardis, Roozbeh Houshyar, Chanon Chantaduly, Karen Tran-Harding, Alexander Ushinsky, Chantal Chahine, Mark Rupasinghe, Daniel Chow, Peter Chang

Open access · diamondAbstract read
In one paragraph

Article in Radiology. Imaging cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Pooled it
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  3. Integrating Artificial Intelligence into Prostate MR Imaging: Technical Foundations, Clinical Applications, and Workflow Implications.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Michelle BardisFrom the Department of Radiological Sciences, University of California, Irvine, 101 The City Drive South, Building 55, Suite 201, Orange, CA 92868 (M.B., R.H., K.T.H., C. Chahine, M.R.); Center for Artificial Intelligence in Diagnostic Medicine, University of California, Irvine, Irvine, Calif (C. Chantaduly, D.C., P.C.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (A.U.).ORCID 0000-0002-3223-2127
Roozbeh HoushyarFrom the Department of Radiological Sciences, University of California, Irvine, 101 The City Drive South, Building 55, Suite 201, Orange, CA 92868 (M.B., R.H., K.T.H., C. Chahine, M.R.); Center for Artificial Intelligence in Diagnostic Medicine, University of California, Irvine, Irvine, Calif (C. Chantaduly, D.C., P.C.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (A.U.).
Chanon ChantadulyFrom the Department of Radiological Sciences, University of California, Irvine, 101 The City Drive South, Building 55, Suite 201, Orange, CA 92868 (M.B., R.H., K.T.H., C. Chahine, M.R.); Center for Artificial Intelligence in Diagnostic Medicine, University of California, Irvine, Irvine, Calif (C. Chantaduly, D.C., P.C.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (A.U.).
Karen Tran-HardingFrom the Department of Radiological Sciences, University of California, Irvine, 101 The City Drive South, Building 55, Suite 201, Orange, CA 92868 (M.B., R.H., K.T.H., C. Chahine, M.R.); Center for Artificial Intelligence in Diagnostic Medicine, University of California, Irvine, Irvine, Calif (C. Chantaduly, D.C., P.C.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (A.U.).
Alexander UshinskyFrom the Department of Radiological Sciences, University of California, Irvine, 101 The City Drive South, Building 55, Suite 201, Orange, CA 92868 (M.B., R.H., K.T.H., C. Chahine, M.R.); Center for Artificial Intelligence in Diagnostic Medicine, University of California, Irvine, Irvine, Calif (C. Chantaduly, D.C., P.C.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (A.U.).
Chantal ChahineFrom the Department of Radiological Sciences, University of California, Irvine, 101 The City Drive South, Building 55, Suite 201, Orange, CA 92868 (M.B., R.H., K.T.H., C. Chahine, M.R.); Center for Artificial Intelligence in Diagnostic Medicine, University of California, Irvine, Irvine, Calif (C. Chantaduly, D.C., P.C.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (A.U.).
Mark RupasingheFrom the Department of Radiological Sciences, University of California, Irvine, 101 The City Drive South, Building 55, Suite 201, Orange, CA 92868 (M.B., R.H., K.T.H., C. Chahine, M.R.); Center for Artificial Intelligence in Diagnostic Medicine, University of California, Irvine, Irvine, Calif (C. Chantaduly, D.C., P.C.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (A.U.).ORCID 0000-0002-2615-5356
Daniel ChowFrom the Department of Radiological Sciences, University of California, Irvine, 101 The City Drive South, Building 55, Suite 201, Orange, CA 92868 (M.B., R.H., K.T.H., C. Chahine, M.R.); Center for Artificial Intelligence in Diagnostic Medicine, University of California, Irvine, Irvine, Calif (C. Chantaduly, D.C., P.C.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (A.U.).
Peter ChangFrom the Department of Radiological Sciences, University of California, Irvine, 101 The City Drive South, Building 55, Suite 201, Orange, CA 92868 (M.B., R.H., K.T.H., C. Chahine, M.R.); Center for Artificial Intelligence in Diagnostic Medicine, University of California, Irvine, Irvine, Calif (C. Chantaduly, D.C., P.C.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (A.U.).
University of California, Irvine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose To develop a deep learning model to delineate the transition zone (TZ) and peripheral zone (PZ) of the prostate on MR images. Materials and Methods This retrospective study was composed of patients who underwent a multiparametric prostate MRI and an MRI/transrectal US fusion biopsy between January 2013 and May 2016. A board-certified abdominal radiologist manually segmented the prostate, TZ, and PZ on the entire data set. Included accessions were split into 60% training, 20% validation, and 20% test data sets for model development. Three convolutional neural networks with a U-Net architecture were trained for automatic recognition of the prostate organ, TZ, and PZ. Model performance for segmentation was assessed using Dice scores and Pearson correlation coefficients. Results A total of 242 patients were included (242 MR images; 6292 total images). Models for prostate organ segmentation, TZ segmentation, and PZ segmentation were trained and validated. Using the test data set, for prostate organ segmentation, the mean Dice score was 0.940 (interquartile range, 0.930-0.961), and the Pearson correlation coefficient for volume was 0.981 (95% CI: 0.966, 0.989). For TZ segmentation, the mean Dice score was 0.910 (interquartile range, 0.894-0.938), and the Pearson correlation coefficient for volume was 0.992 (95% CI: 0.985, 0.995). For PZ segmentation, the mean Dice score was 0.774 (interquartile range, 0.727-0.832), and the Pearson correlation coefficient for volume was 0.927 (95% CI: 0.870, 0.957). Conclusion Deep learning with an architecture composed of three U-Nets can accurately segment the prostate, TZ, and PZ.

Indexed as

Deep LearningProstatic NeoplasmsHumansMagnetic Resonance ImagingMaleRetrospective StudiesGenital/ReproductiveMRINeural NetworksProstate

Identifiers

PMID33929265
PMCPMC8189171
OpenAlexW3159396227

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.