ArticleOperative neurosurgery (Hagerstown, Md.)2021
The Unique Fiber Anatomy of Middle Temporal Gyrus Default Mode Connectivity.
Article in Operative neurosurgery (Hagerstown, Md.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Functional brain changes in vascular cognitive impairment: a whole brain ALE meta-analysis.Frontiers in aging neuroscience · 2025Pooled it
- Parcellation-based tractographic modeling of the salience network through meta-analysis.Brain and behavior · 2022Pooled it
- Convergent Functional Changes of Default Mode Network in Mild Cognitive Impairment Using Activation Likelihood Estimation.Frontiers in aging neuroscience · 2021Pooled it
- Frontotemporal bursting supports human working memory.NeuroImage · 2026Article
- A causal deep learning approach to identifying metabolic signatures of cognitive and functional decline in alzheimer's disease.Scientific reports · 2026Article
- Brain structure characteristics in children with attention-deficit/hyperactivity disorder elucidated using traveling-subject harmonization.Molecular psychiatry · 2025Article
- Phase-Specific Contributions and Interactions of the Left and Right Posterior Middle Temporal Gyri in Vocal Feedback Control: Evidence From Dual-Site TMS.Human brain mapping · 2025Article
- Transcriptomic profiling of the middle temporal gyrus reveals differential glial/neuronal dysregulation across Alzheimer's disease and aging.bioRxiv : the preprint server for biology · 2025Article
- Insights into structural deviations in attention deficit hyperactivity disorder (ADHD) and comorbidities using big data-derived brain charts: a cross-sectional study.Quantitative imaging in medicine and surgery · 2025Article
- The Default Mode Network and Visual Network Functional Connectivity Changes in Noise-Induced Hearing Loss Patients: A Resting-State fMRI Study.Brain and behavior · 2025Article
- Alzheimer's disease-like features in resting state EEG/fMRI of cognitively intact and healthy middle-agedJournal of Alzheimer's disease : JAD · 2025Article
- Alterations of interhemispheric functional connectivity in patients with hypertensive retinopathy using voxel-mirrored homotopic connectivity: a resting state fMRI study.International journal of ophthalmology · 2025Article
- Functional connectivity between the uncinate fasciculus and frontotemporal semantic system supports reading comprehension in adolescents.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- fNIRS Changes in the Middle Temporal and Occipital Cortices After a Cochlear Implant.The Laryngoscope · 2025Article
- Article
- DFC-Igloo: A dynamic functional connectome learning framework for identifying neurodevelopmental biomarkers in very preterm infants.Computer methods and programs in biomedicine · 2024Article
- Changes in Spatiotemporal Dynamics of Default Network Oscillations between 19 and 29 Years of Age.Brain sciences · 2024Article
- Macronutrient intake is associated with intelligence and neural development in adolescents.Frontiers in nutrition · 2024Article
- The Brain Connectome for Clinical Neuroscience.Advances in experimental medicine and biology · 2024Review
- Disrupted Gray Matter Networks Associated with Cognitive Dysfunction in Cerebral Small Vessel Disease.Brain sciences · 2023Article
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundThe middle temporal gyrus (MTG) is understood to play a role in language-related tasks such as lexical comprehension and semantic cognition. However, a more specific understanding of its key white matter connections could promote the preservation of these functions during neurosurgery.
objectiveTo provide a detailed description of the underlying white matter tracts associated with the MTG to improve semantic preservation during neurosurgery.
methodsTractography was performed using diffusion imaging obtained from 10 healthy adults from the Human Connectome Project. All tracts were mapped between cerebral hemispheres with a subsequent laterality index calculated based on resultant tract volumes. Ten postmortem dissections were performed for ex vivo validation of the tractography based on qualitative visual agreement.
resultsWe identified 2 major white matter bundles leaving the MTG: the inferior longitudinal fasciculus and superior longitudinal fasciculus. In addition to long association fibers, a unique linear sequence of U-shaped fibers was identified, possibly representing a form of visual semantic transfer down the temporal lobe.
conclusionWe elucidate the underlying fiber-bundle anatomy of the MTG, an area highly involved in the brain's language network. Improved understanding of the unique, underlying white matter connections in and around this area may augment our overall understanding of language processing as well as the involvement of higher order cerebral networks like the default mode network in these functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.