Evidence map›Paper›PMID 33928577›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2021

siRNA Design and Delivery Based on Carbon Nanotubes.

Danyang Li, Khuloud T Al-Jamal

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. The landscape of nanoparticle-based siRNA delivery and therapeutic development.Molecular therapy : the journal of the American Society of Gene Therapy · 2024
    Review
  2. Article
  3. Research Status and Prospect of Non-Viral Vectors Based on siRNA: A Review.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Danyang LiSchool of Cancer and Pharmaceutical Sciences, King's College London, London, UK.
Khuloud T Al-JamalSchool of Cancer and Pharmaceutical Sciences, King's College London, London, UK. khuloud.al-jamal@kcl.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Owing to the unique physical and chemical properties of carbon nanotubes, they have been widely explored as delivery vectors for proteins, and nucleic acid etc. after functionalization. Particularly, the modification of carbon nanotubes suited for the delivery of siRNA has been intensely studied over the past decade. The assay described in this chapter allows for realizable quantification of siRNA binding on carbon nanotube-based materials using gel electrophoresis and silencing by flow cytometry when the siRNA complexes are delivered in vitro.

Indexed as

Gene Transfer TechniquesRNA InterferenceAnimalsCell Line, TumorElectrophoresis, Agar GelFlow CytometryGene Expression Regulation, NeoplasticLipidsMelanoma, ExperimentalMiceNanotubes, CarbonResearch DesignRNA, Small InterferingSkin NeoplasmsWorkflowLipidsLipofectamineNanotubes, CarbonRNA, Small InterferingBinding capacityCarbon nanotubesCationic polymerN/P ratioSilencing efficiencysiRNA delivery

Identifiers

PMID33928577

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.