Evidence map›Paper›PMID 33928495›Full record

ArticleCardiovascular engineering and technology2021

Prevention of Ischemic Myocardial Contracture Through Hemodynamically Controlled DCD.

Ylva Wahlquist, Kristian Soltesz, Qiuming Liao, Xiaofei Liu, Henry Pigot, Trygve Sjöberg, Stig Steen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular engineering and technology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Ylva WahlquistDepartment of Automatic Control, Lund University, Lund, Sweden. ylva.wahlquist@control.lth.se.
Kristian SolteszDepartment of Automatic Control, Lund University, Lund, Sweden.
Qiuming LiaoDivision of Thoracic Surgery, Department of Clinical Sciences, Lund University, Lund, Sweden.
Xiaofei LiuFirst Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Henry PigotDepartment of Automatic Control, Lund University, Lund, Sweden.
Trygve SjöbergDivision of Thoracic Surgery, Department of Clinical Sciences, Lund University, Lund, Sweden.
Stig SteenDivision of Thoracic Surgery, Department of Clinical Sciences, Lund University, Lund, Sweden.
Lund University · SEFirst Affiliated Hospital of Zhengzhou University · CNSkåne University Hospital · SE

Funding

Vetenskapsrådet 2017-04989
6 · The paper itself

Abstract

purposeIschemic myocardial contracture (IMC) or "stone heart" is a condition with rapid onset following circulatory death. It inhibits transplantability of hearts donated upon circulatory death (DCD). We investigate the effectiveness of hemodynamic normalization upon withdrawal of life-sustaining therapy (WLST) in a large-animal controlled DCD model, with the hypothesis that reduction in cardiac work delays the onset of IMC.

methodsA large-animal study was conducted comprising of a control group ([Formula: see text]) receiving no therapy upon WLST, and a test group ([Formula: see text]) subjected to a protocol for fully automated computer-controlled hemodynamic drug administration. Onset of IMC within 1 h following circulatory death defined the primary end-point. Cardiac work estimates based on pressure-volume loop concepts were developed and used to provide insight into the effectiveness of the proposed computer-controlled therapy.

resultsNo test group individual developed IMC within [Formula: see text], whereas all control group individuals did (4/6 within [Formula: see text]).

conclusionAutomatic dosing of hemodynamic drugs in the controlled DCD context has the potential to prevent onset of IMC up to [Formula: see text], enabling ethical and medically safe organ procurement. This has the potential to increase the use of DCD heart transplantation, which has been widely recognized as a means of meeting the growing demand for donor hearts.

Indexed as

ContractureHeart TransplantationTissue and Organ ProcurementAnimalsHumansMyocardiumTissue DonorsClosed-loop drug administrationDCDHemodynamic controlIschemic damageOrgan preservation

Identifiers

PMID33928495
PMCPMC8481220
OpenAlexW3157855882

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.