Evidence map›Paper›PMID 33928482›Full record

ArticleCancer causes & control : CCC2021

Dietary inflammatory index and risk of colorectal adenoma: effect measure modification by race, nonsteroidal anti-inflammatory drugs, cigarette smoking and body mass index?

Fangcheng Yuan, Lin Deng, Xiangqing Sun, Zhengyi Chen, Nitin Shivappa, Ashutosh K Sheth, Gregory S Cooper, James R Hebert, Li Li

Abstract read
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In one paragraph

Article in Cancer causes & control : CCC, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Fangcheng YuanDepartment of Family Medicine, University of Virginia School of Medicine, McKim Hall Rm 3156, Charlottesville, VA, 22908, USA.
Lin DengDepartment of Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
Xiangqing SunDepartment of Family Medicine, University of Virginia School of Medicine, McKim Hall Rm 3156, Charlottesville, VA, 22908, USA.
Zhengyi ChenDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
Nitin ShivappaDepartment of Epidemiology & Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
Ashutosh K ShethDepartment of Family Medicine, University of Virginia School of Medicine, McKim Hall Rm 3156, Charlottesville, VA, 22908, USA.
Gregory S CooperDepartment of Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
James R HebertDepartment of Epidemiology & Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
Li LiDepartment of Family Medicine, University of Virginia School of Medicine, McKim Hall Rm 3156, Charlottesville, VA, 22908, USA. LL8NV@virginia.edu.
University Hospitals of Cleveland · USUniversity of Virginia · USUniversity of South Carolina · USCase Western Reserve University · US

Funding

15-Hydroxyprostaglandin Dehydrogenase, NSAIDs, Vitamin D, and Coloretcal NeoplasiU01CA181770 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI LI, LI · 2014 to 2017
$2.2M
NCI NIH HHS U01CA181770, P20CA233216, P50CA50964
6 · The paper itself

Abstract

purposeTo investigate if the association between dietary inflammatory potential and colorectal adenoma (CRA) is modified by race and factors known to modulate inflammation.

methodsWe examined effect measure modification of race, nonsteroidal anti-inflammatory drugs (NSAIDs), cigarette smoking and body mass index (BMI) on the diet-CRA association by employing energy-adjusted dietary inflammatory index (E-DII™) to characterize dietary inflammatory potential among 587 cases and 1,313 controls participating in a colonoscopy screening-based cross-sectional study of CRA. Participants completed a food frequency questionnaire from which E-DII score was derived. E-DII score was calculated from 34 food parameters (constituents), utilizing an energy-adjusted global comparative database to compute z scores from which centered proportions were summed to create the score. CRA cases were defined as individuals whose colonoscopy detected at least one pathologically confirmed adenomatous polyp. Unconditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs).

resultsA pro-inflammatory diet was not statistically significantly associated with elevated CRA risk (OR 1.07; 95% CI 0.97-1.19; p value = 0.18) in the multivariate regression model. NSAIDs use (OR

conclusionNSAIDs use and race may modify the diet-CRA association. Further investigation in prospective cohort studies is warranted to confirm these findings.

Indexed as

DietAdenomaAgedAnti-Inflammatory Agents, Non-SteroidalBody Mass IndexCigarette SmokingColonoscopyColorectal NeoplasmsCross-Sectional StudiesFemaleHumansInflammationMaleMiddle AgedRisk FactorsAnti-Inflammatory Agents, Non-SteroidalChronic intestinal inflammationColorectal adenomaDietEffect measure modificationRacial disparity

Identifiers

PMID33928482
OpenAlexW3159371625

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.