Evidence map›Paper›PMID 33928479›Full record

Observational studyClinical and experimental nephrology2021

Factors predicting decline in renal function and kidney volume growth in autosomal dominant polycystic kidney disease: a prospective cohort study (Japanese Polycystic Kidney Disease registry: J-PKD).

Kiyotaka Uchiyama, Toshio Mochizuki, Yosuke Shimada, Saori Nishio, Hiroshi Kataoka, Michihiro Mitobe, Ken Tsuchiya, Kazushige Hanaoka, Yoshifumi Ubara, Tatsuya Suwabe and 11 more

Abstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Clinical and experimental nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Biomolecules · 2023
    Article
  8. Review
  9. Article
  10. Germline Mutations for Kidney Volume in ADPKD.Kidney international reports · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Kiyotaka UchiyamaDivision of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Toshio MochizukiClinical Research Division for Polycystic Kidney Disease, Department of Nephrology, Tokyo Women's Medical University, Tokyo, Japan.
Yosuke ShimadaIntelligent Systems Laboratory, SECOM CO., LTD., Mitaka, Tokyo, Japan.
Saori NishioDivision of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.
Hiroshi KataokaClinical Research Division for Polycystic Kidney Disease, Department of Nephrology, Tokyo Women's Medical University, Tokyo, Japan.
Michihiro MitobeClinical Research Division for Polycystic Kidney Disease, Department of Nephrology, Tokyo Women's Medical University, Tokyo, Japan.
Ken TsuchiyaDepartment of Blood Purification, Tokyo Woman's Medical University, Tokyo, Japan.
Kazushige HanaokaDepartment of General Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.
Yoshifumi UbaraDepartment of Nephrology, Toranomon Hospital, Tokyo, Japan.
Tatsuya SuwabeDepartment of Nephrology, Toranomon Hospital, Tokyo, Japan.
Akinari SekineDepartment of Nephrology, Toranomon Hospital, Tokyo, Japan.
Kikuo NutaharaDepartment of Urology, Kyorin University School of Medicine, Tokyo, Japan.
Kazuhiko TsuruyaDepartment of Integrated Therapy for Chronic Kidney Disease, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Eiji IshimuraDepartment of Nephrology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Shinya NakataniDepartment of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan.
Tadashi SofueDepartment of Cardiorenal and Cerebrovascular Medicine, Kagawa University, Kagawa, Japan.
Satoshi TanakaDepartment of Nephrology, Shizuoka General Hospital, Shizuoka, Japan.
Ichiei NaritaDivision of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medicine and Dental Science, Niigata, Japan.
Shoichi MaruyamaDepartment of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Shigeo HorieDepartment of Advanced Informatics for Genetic Disease, Juntendo University, Tokyo, Japan.
Satoru MutoDepartment of Advanced Informatics for Genetic Disease, Juntendo University, Tokyo, Japan. s-muto@juntendo.ac.jp.ORCID http://orcid.org/0000-0002-5400-5195

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFactors affecting decline in renal function and cyst growth in patients with autosomal polycystic kidney disease (ADPKD) are not fully described, particularly in Japan.

methodsThis was the first multi-facility, prospective, observational cohort study conducted in ADPKD patients at 14 centers in Japan. Patients in the J-PKD registry were assessed from December 2009 to June 2012 (follow-up until June 2017). Patients' data including estimated glomerular filtration rate (eGFR) and total kidney volume (TKV) were assessed initially and a maximum of five times annually. Contributing factors to eGFR decline and TKV growth were identified using multiple linear regression analysis.

resultsOf the 340 patients in the J-PKD registry, data analysis was performed for 192 patients in whom serial changes for both eGFR and TKV were obtained. eGFR slope, eGFR change, and TKV change values were as follows: - 2.7 (- 4.2 to - 1.5) (ml/min/1.73 m

conclusionsThis real-world study in Japan identified risk factors for renal function decline in ADPKD patients. These included lower HDL cholesterol, lower hemoglobin and higher uric acid for eGFR decline, and youth and higher blood sugar levels for TKV growth.

Indexed as

AdultAge FactorsBlood GlucoseCholesterol, HDLDisease ProgressionFastingFemaleFollow-Up StudiesGlomerular Filtration RateHemoglobinsHumansJapanKidneyMaleMiddle AgedOrgan SizeBlood GlucoseCholesterol, HDLHemoglobinsUric AcidAutosomal dominant polycystic kidney diseaseHigh-density lipoprotein cholesterolJ-PKDRenal functionTotal kidney volume

Identifiers

PMID33928479

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.