SynthesisPediatric nephrology (Berlin, Germany)2021
Critical analysis of acute kidney injury in pediatric COVID-19 patients in the intensive care unit.
Synthesis in Pediatric nephrology (Berlin, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05582512 (Clinical Characteristics and Long Term Impact on Pediatric COVID-19 in Taiwan), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Characteristics and Long Term Impact on Pediatric COVID-19 in Taiwan
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Incidence, risk factors and outcomes of acute kidney injury among COVID-19 patients: A systematic review of systematic reviews.Frontiers in medicine · 2022Pooled it
- An Expert Interpretation on the Evolution of oXiris®-Focused Consensus Statements: From Europe to the Asia-Pacific (2019-2024).Blood purification · 2026Article
- Enhancing outcomes in pediatric populations with continuous renal replacement therapy: Current multidisciplinary strategies and innovations.Journal of intensive medicine · 2025Review
- Kidney Function Following COVID-19 in Children and Adolescents.JAMA network open · 2025Article
- Retrospective evaluation of acute kidney injury in paediatric COVID-19 patients: a tertiary referral hospital experience.Journal of nephrology · 2024Observational
- Post-acute and Chronic Kidney Function Outcomes of COVID-19 in Children and Adolescents: An EHR Cohort Study from the RECOVER Initiative.medRxiv : the preprint server for health sciences · 2024Article
- A retrospective analysis of acute kidney injury in children with post-COVID-19 multisystem inflammatory syndrome: insights into promising outcomes.Italian journal of pediatrics · 2024Article
- Acute kidney injury: a post-COVID-19 complication in children and adolescents.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2024Article
- Kidney complications associated with COVID-19 infection and vaccination in children and adolescents: a brief review.Clinical and experimental pediatrics · 2023Article
- Infections and Acute Kidney Injury: A Global Perspective.Seminars in nephrology · 2023Review
- Post-COVID-19 effect on biochemical parameters in children: Should we take heed?Saudi journal of biological sciences · 2023Article
- COVID-19 and Severe Rhabdomyolysis Causing Acute Kidney Injury and Life-Threatening Hyperkalemia in a Pediatric Patient: a Case Report.SN comprehensive clinical medicine · 2023Article
- Acute Kidney Injury in Children Hospitalized with SARS-CoV-2 Infection.Indian journal of pediatrics · 2022Article
- Acute kidney injury in COVID-19 pediatric patients in North America: Analysis of the virtual pediatric systems data.PloS one · 2022Article
- Acute Vision Loss and Conjunctival Hemorrhage as Telltale Symptoms of PIMS-TS.Global pediatric health · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesCOVID-19 is responsible for the 2019 novel coronavirus disease pandemic. Despite the vast research about the adult population, there has been little data collected on acute kidney injury (AKI) epidemiology, associated risk factors, treatments, and mortality in pediatric COVID-19 patients admitted to the ICU. AKI is a severe complication of COVID-19 among children and adolescents.
methodsA comprehensive literature search was conducted in PubMed/MEDLINE and Cochrane Center Trials to find all published literature related to AKI in COVID-19 patients, including incidence and outcomes.
resultsTwenty-four studies reporting the outcomes of interest were included. Across all studies, the overall sample size of COVID positive children was 1,247 and the median age of this population was 9.1 years old. Among COVID positive pediatric patients, there was an AKI incidence of 30.51%, with only 0.56% of these patients receiving KRT. The mortality was 2.55% among all COVID positive pediatric patients. The incidence of multisystem inflammatory syndrome in children (MIS-C) among COVID positive patients was 74.29%.
conclusionAKI has shown to be a negative prognostic factor in adult patients with COVID-19 and now also in the pediatric cohort with high incidence and mortality rates. Additionally, our findings show a strong comparison in epidemiology between adult and pediatric COVID-19 patients; however, they need to be confirmed with additional data and studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.