Evidence map›Paper›PMID 33928435›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2021

Postural differences in the immediate effects of active exercise with compression therapy on lower limb lymphedema.

Kiriko Abe, Tetsuya Tsuji, Asako Oka, Junichi Shoji, Michiyo Kamisako, Hiroka Hohri, Aiko Ishikawa, Meigen Liu

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Exercise and cancer-related lymphedema in the lower limbs-a randomized cross-over trial on high-intensity interval training (HIIT) with and without compression garments.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Trial
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. MMW Fortschritte der Medizin · 2023
    Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Kiriko AbeDepartment of Rehabilitation Medicine, Keio University Graduate School of Medicine, 35 Shinanomachi, Shinjyuku-ku, Tokyo, 160-8582, Japan.
Tetsuya TsujiDepartment of Rehabilitation Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjyuku-ku, Tokyo, 160-8582, Japan. cxa01423@nifty.com.ORCID http://orcid.org/0000-0002-4728-9409
Asako OkaDepartment of Rehabilitation Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjyuku-ku, Tokyo, 160-8582, Japan.
Junichi ShojiDepartment of Rehabilitation Medicine, Keio University Hospital, 35 Shinanomachi, Shinjyuku-ku, Tokyo, 160-8582, Japan.
Michiyo KamisakoDepartment of Rehabilitation Medicine, Keio University Hospital, 35 Shinanomachi, Shinjyuku-ku, Tokyo, 160-8582, Japan.
Hiroka HohriDepartment of Rehabilitation Medicine, Keio University Hospital, 35 Shinanomachi, Shinjyuku-ku, Tokyo, 160-8582, Japan.
Aiko IshikawaDepartment of Rehabilitation Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjyuku-ku, Tokyo, 160-8582, Japan.
Meigen LiuDepartment of Rehabilitation Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjyuku-ku, Tokyo, 160-8582, Japan.
Keio University Hospital · JPKeio University · JP

Funding

JSPS KAKENHI 17K01469JSPS KAKENHI 20K11192
6 · The paper itself

Abstract

purposeAlthough regarded as an important treatment for lymphedema, the therapeutic effects of active exercise with compression therapy (AECT) are supported by little evidence. The purpose of this study was to determine the relative benefits of AECT with different postures for patients with lower limb lymphedema (LLL).

methodsEighteen women with LLL secondary to surgical treatment of gynecological cancer, completed (1) AECT in a seated position (seated AECT), (2) AECT in a supine position (supine AECT), and (3) compression-only therapy in a supine position (CT) in this randomized, controlled, crossover trial. AECT was performed on a bicycle ergometer while wearing elastic compression bandages. Each intervention was performed for 15 min, and the three conditions were separated by a 1-week washout period. Lower-limb volumes were evaluated using a Perometer

resultsThe magnitude of limb volume decreases differed significantly among the interventions, with a greater decrease after supine AECT than after CT. Pre-intervention pitting severity and skin stiffness were significantly correlated with the magnitude of volume decrease after all interventions and after AECT in the supine position, respectively.

conclusionsSupine AECT using a bicycle ergometer has marked immediate effects to decrease the fluid volume of severe LLL. CLINICAL

trial registrationUMIN clinical trial registry (UMIN-CTR; ID000020129) by CONSORT 2010, TRN R000023253, December 9, 2015.

Indexed as

LymphedemaCompression BandagesCross-Over StudiesExercise TherapyFemaleHumansLower ExtremityActive exerciseCompression therapyGynecological cancerLymphedemaRehabilitation

Identifiers

PMID33928435
PMCPMC8464559
OpenAlexW3157454737

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.