ArticleEuropean radiology2021
Smaller volume and altered functional connectivity of the amygdala in patients with lifelong premature ejaculation.
Article in European radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Association of sexual dysfunctions according to DSM-5 criteria with structural brain differences in women and men from the Hamburg City Health Study.Dialogues in clinical neuroscience · 2026Article
- Abnormal grey matter in identifying primary intravaginal anejaculation patients from healthy controls: a voxel-based morphometry analysis.Sexual medicine · 2025Article
- Glans penis electric stimulation modulates cerebral activity and functional connectivity in lifelong premature ejaculation revealed by functional MRI.Scientific reports · 2025Article
- Evaluation of neostriatum changes in Crohn's disease: a multimodal brain magnetic resonance imaging study.Quantitative imaging in medicine and surgery · 2024Article
- Altered regional brain activity and functional connectivity in primary intravaginal anejaculation patients revealed by resting-state fMRI.Asian journal of andrology · 2024Article
- Topological differences of striato-thalamo-cortical circuit in functional brain network between premature ejaculation patients with and without depression.Brain and behavior · 2024Article
- Voxel-based morphometry in single subjects without a scanner-specific normal database using a convolutional neural network.European radiology · 2024Article
- Gray matter microstructural alterations in manganese-exposed welders: a preliminary neuroimaging study.European radiology · 2022Article
- Changes of insular function in lifelong premature ejaculation patients before and after SSRI administration.Psychopharmacology · 2022Article
- Hypothalamic-related neural mechanism in lifelong premature ejaculation and trends following selective serotonin reuptake inhibitor administration.CNS neuroscience & therapeutics · 2022Article
- Potential biomarkers for distinguishing primary from acquired premature ejaculation: A diffusion tensor imaging based network study.Frontiers in neuroscience · 2022Article
- Multivariate Pattern Analysis of Lifelong Premature Ejaculation Based on Multiple Kernel Support Vector Machine.Frontiers in psychiatry · 2022Article
- Convergent and Divergent Structural Connectivity of Brain White Matter Network Between Patients With Erectile Dysfunction and Premature Ejaculation: A Graph Theory Analysis Study.Frontiers in neurology · 2022Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesTo analyze the abnormal amygdala structure and function in lifelong premature ejaculation (PE) patients compared with healthy controls (HCs).
methodsForty-four lifelong PE patients and thirty-one HCs were enrolled in this study. Each subject was diagnosed with PE using a Premature Ejaculation Diagnostic Tool (PEDT) and intravaginal ejaculation latency time (IELT) score. Based on t-tests and Pearson correlation analysis, the voxel-based morphometry and functional connectivity (FC) analyses were applied to evaluate brain structural and functional changes by using T1-weighted and resting-state functional magnetic resonance imaging scans.
resultsLifelong PE patients had decreased gray matter volume in the bilateral amygdala and increased FC between the amygdala and precuneus, posterior cingulate cortex (PCC), and middle temporal cortex (MTC), as well as decreased FC between the amygdala and precentral gyrus, insula, and inferior frontal gyrus. Moreover, significantly negative correlations between the IELT score and the mean z-score from amygdala-MTC (r = -0.49) and amygdala-PCC (r = -0.48) FC were found in lifelong PE patients.
conclusionsOur study investigated the abnormal amygdala-related structure and connectivity patterns in PE patients, which might provide novel perspective for understanding the crucial role of the amygdala in the neural mechanism of PE. KEY POINTS: • As one of the most common diseases in men, PE may be related to abnormal brain mechanisms. • Functional and structural magnetic resonance imaging used to explore amygdala abnormalities in PE patients. • The correlation between clinical scores and functional connectivity was used to assess the reasonability of the results.
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