ArticleCell reports. Physical science2021
Solid-state packing dictates the unexpected solubility of aromatic peptides.
Article in Cell reports. Physical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- 3D printed, biodegradable, and biocompatible intraperitoneal implants loaded with folic acid-targeted/pH-sensitive/doxorubicin-loaded hydroxyapatite nanoparticles for systemic treatment of metastatic breast cancer.Journal of nanobiotechnology · 2025Article
- Understanding and fine tuning the propensity of ATP-driven liquid-liquid phase separation with oligolysine.Physical chemistry chemical physics : PCCP · 2024Article
- Predicting absolute aqueous solubility by applying a machine learning model for an artificially liquid-state as proxy for the solid-state.Journal of computer-aided molecular design · 2023Article
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Authors and funding
12 authors.
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Abstract
The understanding and prediction of the solubility of biomolecules, even of the simplest ones, reflect an open question and unmet need. Short aromatic tripeptides are among the most highly aggregative biomolecules. However, in marked contrast, Ala-Phe-Ala (AFA) was surprisingly found to be non-aggregative and could be solubilized at millimolar concentrations. Here, aiming to uncover the underlying molecular basis of its high solubility, we explore in detail the solubility, aggregation propensity, and atomic-level structure of the tripeptide. We demonstrate an unexpectedly high water solubility of AFA reaching 672 mM, two orders of magnitude higher than reported previously. The single crystal structure reveals an anti-parallel β sheet conformation devoid of any aromatic interactions. This study provides clear mechanistic insight into the structural basis of solubility and suggests a simple and feasible tool for its estimation, bearing implications for design of peptide drugs, peptides materials, and advancement of peptide nanotechnology.
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Registered trials
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