Evidence map›Paper›PMID 33927912›Full record

ArticleACS catalysis2020

Oxidative Photocatalytic Homo- and Cross-Coupling of Phenols: Nonenzymatic, Catalytic Method for Coupling Tyrosine.

Kyle A Niederer, Philip H Gilmartin, Marisa C Kozlowski

Abstract read
In one paragraph

Article in ACS catalysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Photocatalytic coupling of phenols with iminesOrganic chemistry frontiers : an international journal of organic chemistry · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Visible-light TiOChemical science · 2024
    Article
  10. CspChemical science · 2024
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Edge-Decorated Polycyclic Aromatic Hydrocarbons by an Oxidative Coupling Approach.Chemistry (Weinheim an der Bergstrasse, Germany) · 2023
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kyle A NiedererDepartment of Chemistry, Roy and Diana Vagelos Laboratories, University of Pennsylvania, Philadelphia, Pennsylvania 19014, United States.
Philip H GilmartinDepartment of Chemistry, Roy and Diana Vagelos Laboratories, University of Pennsylvania, Philadelphia, Pennsylvania 19014, United States.
Marisa C KozlowskiDepartment of Chemistry, Roy and Diana Vagelos Laboratories, University of Pennsylvania, Philadelphia, Pennsylvania 19014, United States.

Funding

Computation and Development of New, Enabling Synthetic MethodsR35GM131902 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Marisa C Kozlowski · 2019 to 2026
$4.5M
NMR SYSTEMS : 2 BRUKER AVANCE 500 CONSOLESS10RR022442 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI SMITH, AMOS B · 2006 to 2006
$500k
Purchase of a Mass Directed Liquid ChromatographS10OD011980 · OD · UNIVERSITY OF PENNSYLVANIA · PI KOZLOWSKI, MARISA C · 2012 to 2012
$372k
Time-Of-Flight Instrument with Variable Ionization SourcesS10RR023444 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI DMOCHOWSKI, IVAN JULIAN · 2007 to 2007
$308k
NCRR NIH HHS S10 RR022442NCRR NIH HHS S10 RR023444NIGMS NIH HHS R35 GM131902NIH HHS S10 OD011980
6 · The paper itself

Abstract

The oxidative photocatalytic method for phenol-phenol homo-coupling and cross-coupling is described and isolated yields of 16-97% are obtained. Measured oxidation potentials and computed nucleophilicity parameters support a mechanism of nucleophilic attack of one partner onto the oxidized neutral radical form of the other partner. Understanding of this model permitted development of cross-coupling reactions between nucleophilic phenols/arenes and easily oxidized phenols with high selectivity and efficiency. A highlight of this method is that one equivalent of each coupling partner is utilized. Building on these findings, a non-enzymatic, catalytic method for coupling tyrosine was also developed.

Indexed as

cross-couplingOxidative couplingphenol couplingphotocatalysistyrosine dimerization

Identifiers

PMID33927912
PMCPMC8078885

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.