Evidence map›Paper›PMID 33927636›Full record

ArticleFrontiers in physiology2021

KCNQ Current Contributes to Inspiratory Burst Termination in the Pre-Bötzinger Complex of Neonatal Rats

Ann L Revill, Alexis Katzell, Christopher A Del Negro, William K Milsom, Gregory D Funk

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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  8. Evidence for Dual Activation ofInternational journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Ann L RevillNeuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.
Alexis KatzellNeuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.
Christopher A Del NegroDepartment of Applied Science, William & Mary, Williamsburg, VA, United States.
William K MilsomDepartment of Zoology, University of British Columbia, Vancouver, BC, Canada.
Gregory D FunkNeuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.
University of Alberta · CAUniversity of British Columbia · CAWilliams (United States) · USWomen and Children’s Health Research Institute · CA

Funding

Ion Channel Mechanisms of Inspiratory Breathing Movements in MiceR01NS107296 · NINDS · COLLEGE OF WILLIAM AND MARY · PI DEL NEGRO, CHRISTOPHER A. · 2019 to 2022
$1.1M
NINDS NIH HHS R01 NS107296
6 · The paper itself

Abstract

The pre-Bötzinger complex (preBötC) of the ventral medulla generates the mammalian inspiratory breathing rhythm. When isolated in explants and deprived of synaptic inhibition, the preBötC continues to generate inspiratory-related rhythm. Mechanisms underlying burst generation have been investigated for decades, but cellular and synaptic mechanisms responsible for burst termination have received less attention. KCNQ-mediated K

Indexed as

breathinginspiratory rhythmKCNQKv7M-currentrespiration

Identifiers

PMID33927636
PMCPMC8078421
OpenAlexW3156409856

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.