ReviewFrontiers in neuroscience2021
Trigeminal Nerve Control of Cerebral Blood Flow: A Brief Review.
Review in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Acupuncture treatment of vascular cognitive impairment through peripheral nerve stimulation pathway: a scoping review.Frontiers in aging neuroscience · 2025Pooled it
- Exploring the Relationship Between Cerebral Blood Flow and Oral Exercise Using Head-Mounted Near-Infrared Spectroscopy.Dysphagia · 2026Article
- Hallmarks of headache disorders: part 5 - secondary headaches.The journal of headache and pain · 2026Review
- Acupuncture for Post-Stroke Cognitive Impairment: Mechanisms and Clinical Evidence (2020-2025).Neuropsychiatric disease and treatment · 2026Review
- Mandibular extension as a trigger of the proprioceptive trigeminocardiac reflex.Turkish journal of medical sciences · 2026Review
- Facial Clefts and the Trigeminal Nerve: A Narrative Review of the Literature and Clinical Considerations in the Era of Personalized Medicine.Journal of personalized medicine · 2025Review
- Vasoactive neuropeptide dysregulation: A novel mechanism of microvascular dysfunction in vascular cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Ocular neuromodulation as a novel treatment for retinitis pigmentosa: identifying rod responders and predictors of visual improvement.International journal of retina and vitreous · 2025Article
- Review
- Developing a multiscale neural connectivity knowledgebase of the autonomic nervous system.Frontiers in neuroinformatics · 2025Article
- External trigeminal nerve stimulation for neuropsychiatric disorders: mechanisms, efficacy, and future directions.Frontiers in neurology · 2025Review
- Cardiac Arrest during Temporary Clipping for Ruptured Internal Carotid Artery Aneurysm: A Case Report.Asian journal of neurosurgery · 2024Article
- Neurosurgical Complications Following Tooth Extraction: A Systematic Review and Individual Patient Meta-Analysis : Neurosurgical Complications Following Tooth Extraction.Galen medical journal · 2024Review
- Trigeminal nerve stimulation: a current state-of-the-art review.Bioelectronic medicine · 2023Review
- Neurophysiology, Neuro-Immune Interactions, and Mechanobiology in Osteopathy in the Cranial Field: An Evidence-Informed Perspective for a Scientific Rationale.Healthcare (Basel, Switzerland) · 2023Article
- Cognitive Functions following Trigeminal Neuromodulation.Biomedicines · 2023Review
- Dental procedure induced cerebellar haemorrhage with visual tilt and unsuspected CADASIL.BMJ case reports · 2023Article
- Calcitonin Gene-Related Peptide mRNA Synthesis in Trigeminal Ganglion Neurons after Cortical Spreading Depolarization.International journal of molecular sciences · 2023Article
- Optimal acupuncture protocol improving symptoms of typical dry eye syndrome: meta-analysis and systematic review.Heliyon · 2023Article
- Neural control of cerebral blood flow: scientific basis of scalp acupuncture in treating brain diseases.Frontiers in neuroscience · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The trigeminal nerve, the fifth cranial nerve, is known to innervate much of the cerebral arterial vasculature and significantly contributes to the control of cerebrovascular tone in both healthy and diseased states. Previous studies have demonstrated that stimulation of the trigeminal nerve (TNS) increases cerebral blood flow (CBF) via antidromic, trigemino-parasympathetic, and other central pathways. Despite some previous reports on the role of the trigeminal nerve and its control of CBF, there are only a few studies that investigate the effects of TNS on disorders of cerebral perfusion (i.e., ischemic stroke, subarachnoid hemorrhage, and traumatic brain injury). In this mini review, we present the current knowledge regarding the mechanisms of trigeminal nerve control of CBF, the anatomic underpinnings for targeted treatment, and potential clinical applications of TNS, with a focus on the treatment of impaired cerebral perfusion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.