Evidence map›Paper›PMID 33927388›Full record

ArticleNature structural & molecular biology2021

The structure of a virus-encoded nucleosome.

Marco Igor Valencia-Sánchez, Stephen Abini-Agbomson, Miao Wang, Rachel Lee, Nikita Vasilyev, Jenny Zhang, Pablo De Ioannes, Bernard La Scola, Paul Talbert, Steve Henikoff and 3 more

Open access · greenAbstract read
In one paragraph

Article in Nature structural & molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 71 citations in OpenAlex.

  1. Review
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  19. Nucleosomes at the Dawn of Eukaryotes.Genome biology and evolution · 2024
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Marco Igor Valencia-Sánchez *Skirball Institute of Biomolecular Medicine, Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA.
Stephen Abini-Agbomson *Skirball Institute of Biomolecular Medicine, Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-0148-6498
Miao WangSkirball Institute of Biomolecular Medicine, Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA.
Rachel LeeSkirball Institute of Biomolecular Medicine, Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-2501-5973
Nikita VasilyevDepartment of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA.
Jenny ZhangSkirball Institute of Biomolecular Medicine, Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA.
Pablo De IoannesSkirball Institute of Biomolecular Medicine, Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-1944-3912
Bernard La ScolaInstitut de Recherche Pour le Développement (IRD), Assistance Publique - Hôpitaux de Marseille (AP-HM), MEPHI, Aix-Marseille University, Marseille, France.
Paul TalbertHoward Hughes Medical Institute, Chevy Chase, MD, USA.ORCID http://orcid.org/0000-0003-2563-3878
Steve HenikoffHoward Hughes Medical Institute, Chevy Chase, MD, USA.ORCID http://orcid.org/0000-0002-7621-8685
Evgeny NudlerDepartment of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-8811-3071
Albert ErivesDepartment of Biology, University of Iowa, Iowa City, IA, USA.ORCID http://orcid.org/0000-0001-7107-5518
Karim-Jean ArmacheSkirball Institute of Biomolecular Medicine, Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA. karim-jean.armache@nyulangone.org.ORCID http://orcid.org/0000-0002-0890-9513
New York University · USHoward Hughes Medical Institute · USAix-Marseille Université · FRUniversity of Iowa · US

Funding

TRD #3: An automated and streamlined pipeline for in-situ molecular microscopyP41GM103310 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2012 to 2021
$14.7M
Molecular Structure Determination by Mass Spectrometry and Computational ModelingR01GM127267 · NIGMS · UNIVERSITY OF MISSISSIPPI · PI Joshua S Sharp · 2018 to 2026
$3.8M
Dual-Beam Scanning Electron Microscope for New York Structural Biology CenterS10RR029300 · NCRR · NEW YORK STRUCTURAL BIOLOGY CENTER · PI STOKES, DAVID L. · 2010 to 2010
$2.0M
Training program in Molecular BiophysicsT32GM088118 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI STOKES, DAVID L. · 2010 to 2019
$1.8M
Acquisition of Detector for JEOL 3200 FSC Electron MicroscopeS10OD019994 · OD · NEW YORK STRUCTURAL BIOLOGY CENTER · PI CARRAGHER, BRIDGET OLIVIA · 2015 to 2015
$600k
Howard Hughes Medical InstituteNCRR NIH HHS S10 RR029300NIGMS NIH HHS P41 GM103310NIGMS NIH HHS R01 GM127267NIGMS NIH HHS T32 GM088118NIH HHS S10 OD019994
6 · The paper itself

Abstract

Certain large DNA viruses, including those in the Marseilleviridae family, encode histones. Here we show that fused histone pairs Hβ-Hα and Hδ-Hγ from Marseillevirus are structurally analogous to the eukaryotic histone pairs H2B-H2A and H4-H3. These viral histones form 'forced' heterodimers, and a heterotetramer of four such heterodimers assembles DNA to form structures virtually identical to canonical eukaryotic nucleosomes.

Indexed as

DNADNA VirusesHistonesNucleosomesProtein BindingProtein Structural ElementsProtein Structure, TertiaryDNAHistonesNucleosomes

Identifiers

PMID33927388
PMCPMC8370576
OpenAlexW3159784679

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.