Evidence map›Paper›PMID 33927318›Full record

ArticleScientific reports2021

Inducible knockout of Clec16a in mice results in sensory neurodegeneration.

Heather S Hain, Rahul Pandey, Marina Bakay, Bryan P Strenkowski, Danielle Harrington, Micah Romer, William W Motley, Jian Li, Eunjoo Lancaster, Lindsay Roth and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Heather S HainThe Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA. hainh@email.chop.edu.
Rahul PandeyThe Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Marina BakayThe Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Bryan P StrenkowskiThe Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Danielle HarringtonThe Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Micah RomerDepartment of Neurology, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
William W MotleyDepartment of Neurology, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Jian LiDepartment of Neurology, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Eunjoo LancasterDepartment of Neurology, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Lindsay RothDepartment of Neurology, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Judith B GrinspanDepartment of Neurology, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Steven S Scherer *Department of Neurology, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Hakon Hakonarson *The Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA. hakonarson@email.chop.edu.
University of Pennsylvania · USChildren's Hospital of Philadelphia · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CLEC16A has been shown to play a role in autophagy/mitophagy processes. Additionally, genetic variants in CLEC16A have been implicated in multiple autoimmune diseases. We generated an inducible whole-body knockout, Clec16a

Indexed as

Nervous System Autoimmune Disease, ExperimentalSpinocerebellar AtaxiasAnimalsCytokinesFemaleGene Knockout TechniquesLectins, C-TypeMaleMiceMice, KnockoutMonosaccharide Transport ProteinsNeuronsUbiquitinsCLEC16A protein, mouseCytokinesG1p2 protein, mouseLectins, C-TypeMonosaccharide Transport ProteinsUbiquitins

Identifiers

PMID33927318
PMCPMC8084945
OpenAlexW3159423605

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.