Evidence map›Paper›PMID 33927302›Full record

ArticleScientific reports2021

Improved chondrogenic performance with protective tracheal design of Chitosan membrane surrounding 3D-printed trachea.

Hyeonji Kim, Jae Yeon Lee, Hyeonseok Han, Won-Woo Cho, Hohyeon Han, Andrew Choi, Hyeonjun Hong, Jae Yun Kim, Jeong Hun Park, Sun Hwa Park and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Hyeonji Kim *Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), 37673, Pohang, Gyeongbuk, South Korea.
Jae Yeon Lee *Department of Companion Animal Health, Daegu Haany University, 38610, Gyeongsan, Gyeongbuk, South Korea.
Hyeonseok Han *Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), 37673, Pohang, Gyeongbuk, South Korea.
Won-Woo ChoDepartment of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), 37673, Pohang, Gyeongbuk, South Korea.
Hohyeon HanSchool of Interdisciplinary Bioscience and Bioengineering (POSTECH), 37673, Pohang, Gyeongbuk, South Korea.
Andrew ChoiDepartment of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), 37673, Pohang, Gyeongbuk, South Korea.
Hyeonjun HongDepartment of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), 37673, Pohang, Gyeongbuk, South Korea.
Jae Yun KimSchool of Interdisciplinary Bioscience and Bioengineering (POSTECH), 37673, Pohang, Gyeongbuk, South Korea.
Jeong Hun ParkDepartment of Biomedical Engineering, The Wallace H. Coulter, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Sun Hwa ParkDepartment of Otolaryngology and HNS, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Sung Won KimDepartment of Otolaryngology and HNS, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Dong Sung KimDepartment of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), 37673, Pohang, Gyeongbuk, South Korea. smkds@postech.ac.kr.
Dong-Woo ChoDepartment of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), 37673, Pohang, Gyeongbuk, South Korea. dwcho@postech.ac.kr.
Pohang University of Science and Technology · KRCatholic University of Korea · KRDaegu Haany University · KRGeorgia Institute of Technology · USYonsei University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent tracheal tissue engineering, limitations in cartilage reconstruction, caused by immature delivery of chondrocyte-laden components, have been reported beyond the complete epithelialization and integration of the tracheal substitutes with the host tissue. In an attempt to overcome such limitations, this article introduces a protective design of tissue-engineered trachea (TraCHIM) composed of a chitosan-based nanofiber membrane (CHIM) and a 3D-printed biotracheal construct. The CHIM was created from chitosan and polycaprolactone (PCL) using an electrospinning process. Upon addition of chitosan to PCL, the diameter of electrospun fibers became thinner, allowing them to be stacked more closely, thereby improving its mechanical properties. Chitosan also enhances the hydrophilicity of the membranes, preventing them from slipping and delaminating over the cell-laden bioink of the biotracheal graft, as well as protecting the construct. Two weeks after implantation in Sprague-Dawley male rats, the group with the TraCHIM exhibited a higher number of chondrocytes, with enhanced chondrogenic performance, than the control group without the membrane. This study successfully demonstrates enhanced chondrogenic performance of TraCHIM in vivo. The protective design of TraCHIM opens a new avenue in engineered tissue research, which requires faster tissue formation from 3D biodegradable materials, to achieve complete replacement of diseased tissue.

Indexed as

ChondrogenesisAnimalsChitosanChondrocytesHumansMalePolyestersPrinting, Three-DimensionalRatsRats, Sprague-DawleyTissue EngineeringTissue ScaffoldsTracheaChitosanpolycaprolactonePolyesters

Identifiers

PMID33927302
PMCPMC8085235
OpenAlexW3132018504

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.