ArticleScientific reports2021
The Voronoi theory of the normal liver lobular architecture and its applicability in hepatic zonation.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed.
- DANEELpath open source digital analysis tools for histopathological research in neuroblastoma models.Scientific reports · 2026Article
- Endodermal cells use contact inhibition of locomotion to achieve uniform cell dispersal during zebrafish gastrulation.iScience · 2025Article
- Computer-Aided Diagnosis of Equine Pharyngeal Lymphoid Hyperplasia Using the Object Detection-Based Processing Technique of Digital Endoscopic Images.Animals : an open access journal from MDPI · 2025Article
- Compartmentalization, cooperation, and communication: The 3Cs of Hepatocyte zonation.Current opinion in cell biology · 2024Review
- Cross-species variability in lobular geometry and cytochrome P450 hepatic zonation: insights into CYP1A2, CYP2D6, CYP2E1 and CYP3A4.Frontiers in pharmacology · 2024Article
- How single-cell transcriptomics provides insight on hepatic responses to TCDD.Current opinion in toxicology · 2023Article
- Zonated quantification of immunohistochemistry in normal and steatotic livers.Virchows Archiv : an international journal of pathology · 2023Article
- Evaluation of the Spatial Arrangement of Rabbit Hepatocytes Based on Voronoi Tessellation Following Exposure to Zinc Oxide Nanoparticles.Avicenna journal of medical biotechnologyArticle
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7 authors.
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Abstract
The precise characterization of the lobular architecture of the liver has been subject of investigation since the earliest historical publications, but an accurate model to describe the hepatic lobular microanatomy is yet to be proposed. Our aim was to evaluate whether Voronoi diagrams can be used to describe the classic liver lobular architecture. We examined the histology of normal porcine and human livers and analyzed the geometric relationships of various microanatomic structures utilizing digital tools. The Voronoi diagram model described the organization of the hepatic classic lobules with overall accuracy nearly 90% based on known histologic landmarks. We have also designed a Voronoi-based algorithm of hepatic zonation, which also showed an overall zonal accuracy of nearly 90%. Therefore, we have presented evidence that Voronoi diagrams represent the basis of the two-dimensional organization of the normal liver and that this concept may have wide applicability in liver pathology and research.
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