Evidence map›Paper›PMID 33927258›Full record

ArticleScientific reports2021

The dimer-monomer equilibrium of SARS-CoV-2 main protease is affected by small molecule inhibitors.

Lucia Silvestrini, Norhan Belhaj, Lucia Comez, Yuri Gerelli, Antonino Lauria, Valeria Libera, Paolo Mariani, Paola Marzullo, Maria Grazia Ortore, Antonio Palumbo Piccionello and 4 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
9.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 90 citations in OpenAlex.

  1. The C117D oxidation mimic reveals the monomeric structure of SARS-CoV-2 main protease.Protein science : a publication of the Protein Society · 2026
    Article
  2. Article
  3. Slowly exchanging bound states of SARS-CoV-2 3CLStructural dynamics (Melville, N.Y.) · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. MarinePharmaceuticals (Basel, Switzerland) · 2026
    Article
  8. Article
  9. A SARS-CoV-2 MNature communications · 2025
    Article
  10. Journal of chemical information and modeling · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Phytochemicals in Drug Discovery-A Confluence of Tradition and Innovation.International journal of molecular sciences · 2024
    Review
  19. SARS-CoV-2 3CLPro Dihedral Angles Reveal Allosteric Signaling.bioRxiv : the preprint server for biology · 2024
    Article
  20. SARS-CoV-2 MNature communications · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Lucia SilvestriniDepartment of Life and Environmental Sciences, New York Marche Structural Biology Center (NY-MaSBiC), Marche Polytechnic University, 60131, Ancona, Italy.
Norhan BelhajDepartment of Life and Environmental Sciences, Marche Polytechnic University, 60131, Ancona, Italy.
Lucia ComezDepartment of Physics and Geology, CNR-IOM c/o University of Perugia, 06123, Perugia, Italy.
Yuri GerelliDepartment of Life and Environmental Sciences, Marche Polytechnic University, 60131, Ancona, Italy.
Antonino LauriaSTEBICEF Department, University of Palermo, 90128, Palermo, Italy.
Valeria LiberaDepartment of Physics and Geology, University of Perugia, 06123, Perugia, Italy.
Paolo MarianiDepartment of Life and Environmental Sciences, Marche Polytechnic University, 60131, Ancona, Italy.
Paola MarzulloSTEBICEF Department, University of Palermo, 90128, Palermo, Italy.
Maria Grazia OrtoreDepartment of Life and Environmental Sciences, Marche Polytechnic University, 60131, Ancona, Italy.
Antonio Palumbo PiccionelloSTEBICEF Department, University of Palermo, 90128, Palermo, Italy.
Caterina PetrilloDepartment of Physics and Geology, University of Perugia, 06123, Perugia, Italy.
Lucrezia SaviniDepartment of Life and Environmental Sciences, New York Marche Structural Biology Center (NY-MaSBiC), Marche Polytechnic University, 60131, Ancona, Italy.
Alessandro PaciaroniDepartment of Physics and Geology, University of Perugia, 06123, Perugia, Italy.
Francesco SpinozziDepartment of Life and Environmental Sciences, Marche Polytechnic University, 60131, Ancona, Italy. f.spinozzi@univpm.it.
Marche Polytechnic University · ITUniversity of Perugia · ITUniversity of Palermo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The maturation of coronavirus SARS-CoV-2, which is the etiological agent at the origin of the COVID-19 pandemic, requires a main protease M

Indexed as

Antiviral AgentsComputational BiologyCoronavirus 3C ProteasesCOVID-19DimerizationDrug DiscoveryHumansMolecular Docking SimulationProtease InhibitorsProtein BindingProtein ConformationSARS-CoV-2ThermodynamicsX-Ray DiffractionAntiviral AgentsCoronavirus 3C ProteasesProtease Inhibitors

Identifiers

PMID33927258
PMCPMC8085067
OpenAlexW3158358829

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.