Evidence map›Paper›PMID 33927236›Full record

ArticleScientific reports2021

Allostery of atypical modulators at oligomeric G protein-coupled receptors.

Rabindra V Shivnaraine, Brendan Kelly, Gwendolynne Elmslie, Xi-Ping Huang, Yue John Dong, Margaret Seidenberg, James W Wells, John Ellis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rabindra V ShivnaraineDepartment of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, ON, M5S 3M2, Canada. rvshiv@stanford.edu.
Brendan KellyDepartments of Computer Science, Molecular and Cellular Physiology, and Structural Biology, and Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA, 94305, USA.
Gwendolynne ElmslieDepartments of Psychiatry and Pharmacology, Hershey Medical Center, Penn State University College of Medicine, Hershey, PA, 17033, USA.
Xi-Ping HuangDepartments of Psychiatry and Pharmacology, Hershey Medical Center, Penn State University College of Medicine, Hershey, PA, 17033, USA.
Yue John DongDepartment of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, ON, M5S 3M2, Canada.
Margaret SeidenbergDepartments of Psychiatry and Pharmacology, Hershey Medical Center, Penn State University College of Medicine, Hershey, PA, 17033, USA.
James W WellsDepartment of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, ON, M5S 3M2, Canada. j.wells@utoronto.ca.
John EllisDepartments of Psychiatry and Pharmacology, Hershey Medical Center, Penn State University College of Medicine, Hershey, PA, 17033, USA. johnellis@psu.edu.

Funding

RESPONSES OF SUBPOPULATIONS OF MUSCARINIC RECEPTORSR01AG005214 · NIA · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI ELLIS, JOHN · 1985 to 2011
$2.3M
Responses of Subpopulations of Muscarinic ReceptorsR56AG005214 · NIA · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI ELLIS, JOHN · 2017 to 2017
$618k
NIA NIH HHS R01 AG005214NIA NIH HHS R56 AG005214NIH HHS AG005214
6 · The paper itself

Abstract

Many G protein-coupled receptors (GPCRs) are therapeutic targets, with most drugs acting at the orthosteric site. Some GPCRs also possess allosteric sites, which have become a focus of drug discovery. In the M

Indexed as

Allosteric RegulationAllosteric SiteAnimalsCHO CellsCricetinaeCricetulusLigandsMolecular Dynamics SimulationReceptor, Muscarinic M2TacrineLigandsReceptor, Muscarinic M2Tacrine

Identifiers

PMID33927236
PMCPMC8085029

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.