ArticleScientific reports2021
KLK3 SNP-SNP interactions for prediction of prostate cancer aggressiveness.
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Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11citing papers in PubMed
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Who cites it
11 citing papers in PubMed.
- Polygenic risk score with KLK3 SNP-SNP interaction pairs for predicting prostate cancer aggressiveness.Communications medicine · 2026Article
- Association of selectedPathology oncology research : POR · 2026Article
- Exploring the therapeutic effect of melatonin targeting common biomarkers in testicular germ cell tumor, prostate adenocarcinoma, and male infertility: an integrated biology approach.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Article
- Heterogeneous genetic architectures of prostate cancer susceptibility in sub-Saharan Africa.Nature genetics · 2024Article
- Cluster effect for SNP-SNP interaction pairs for predicting complex traits.Scientific reports · 2024Article
- Biophysical and biochemical aspects of immune cell-tumor microenvironment interactions.APL bioengineering · 2024Review
- Heterogeneous genetic architectures and evolutionary genomics of prostate cancer in Sub-Saharan Africa.Research square · 2023Article
- Abandon the Label of Clinically Insignificant Prostate Cancer.European urology open science · 2022Article
- KLK3 in the Regulation of Angiogenesis-Tumorigenic or Not?International journal of molecular sciences · 2021Review
- SNPxE: SNP-environment interaction pattern identifier.BMC bioinformatics · 2021Article
- Could Kallikrein-Related Serine Peptidase 3 Be an Early Biomarker of Environmental Exposure in Young Women?International journal of environmental research and public health · 2021Article
Corrections and comments
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Authors and funding
47 authors.
Hui-Yi LinBiostatistics Program, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA, 70112, USA. hlin1@lsuhsc.edu.
Po-Yu HuangComputational Intelligence Technology Center, Industrial Technology Research Institute, Hsinchu, Taiwan.
Chia-Ho ChengDepartment of Biostatistics and Bioinformatics, Moffitt Cancer Center & Research Institute, Tampa, FL, 33612, USA.
Heng-Yuan TungBiostatistics Program, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA, 70112, USA.
Zhide FangBiostatistics Program, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA, 70112, USA.
Anders E BerglundDepartment of Biostatistics and Bioinformatics, Moffitt Cancer Center & Research Institute, Tampa, FL, 33612, USA.
Ann ChenDepartment of Biostatistics and Bioinformatics, Moffitt Cancer Center & Research Institute, Tampa, FL, 33612, USA.
Jennifer French-KwawuBiostatistics Program, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA, 70112, USA.
Darian HarrisBiostatistics Program, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA, 70112, USA.
Julio Pow-SangDepartment of Genitourinary Oncology, Moffitt Cancer Center & Research Institute, Tampa, FL, 33612, USA.
Kosj YamoahDepartment of Radiation Oncology, Moffitt Cancer Center & Research Institute, Tampa, FL, 33612, USA.
John L ClevelandDepartment of Tumor Biology, Moffitt Cancer Center & Research Institute, Tampa, FL, 33612, USA.
Shivanshu AwasthiDepartment of Cancer Epidemiology, Moffitt Cancer Center & Research Institute, Tampa, FL, 33612, USA.
Robert J RounbehlerDepartment of Tumor Biology, Moffitt Cancer Center & Research Institute, Tampa, FL, 33612, USA.
Travis GerkeDepartment of Cancer Epidemiology, Moffitt Cancer Center & Research Institute, Tampa, FL, 33612, USA.
Jasreman DhillonDepartment of Pathology, Moffitt Cancer Center & Research Institute, Tampa, FL, 33612, USA.
Rosalind EelesThe Institute of Cancer Research, London, SM2 5NG, UK.
Zsofia Kote-JaraiThe Institute of Cancer Research, London, SM2 5NG, UK.
Kenneth MuirDivision of Population Health, Health Services Research, and Primary Care, University of Manchester, Oxford Road, Manchester, M139PT, UK.
UKGPCS collaborators
Johanna SchleutkerInstitute of Biomedicine, University of Turku, Kiinamyllynkatu 10, 20014, Turku, Finland.
Nora PashayanDepartment of Applied Health Research, University College London, London, UK.
APCB (Australian Prostate Cancer BioResource)
David E NealNuffield Department of Surgical Sciences, University of Oxford, Room 6603, Level 6, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9DU, UK.
Sune F NielsenHealth and Medical Sciences, University of Copenhagen, 2200, Copenhagen, Denmark.
Børge G NordestgaardHealth and Medical Sciences, University of Copenhagen, 2200, Copenhagen, Denmark.
Henrik GronbergDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
Fredrik WiklundDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
Graham G GilesCancer Epidemiology Division, Cancer Council Victoria, 615 St Kilda Road, Melbourne, VIC, 3004, Australia.
Christopher A HaimanCenter for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, 90015, USA.
Ruth C TravisCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
Janet L StanfordDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109-1024, USA.
Adam S KibelDivision of Urologic Surgery, Brigham and Womens Hospital, 75 Francis Street, Boston, MA, 02115, USA.
Cezary CybulskiDepartment of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.
Kay-Tee KhawClinical Gerontology Unit, University of Cambridge, Cambridge, CB2 2QQ, UK.
Christiane MaierHumangenetik Tuebingen, Paul-Ehrlich-Str 23, 72076, Tuebingen, Germany.
Stephen N ThibodeauDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA.
Manuel R TeixeiraDepartment of Genetics, Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal.
Lisa Cannon-AlbrightDivision of Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
Radka KanevaDepartment of Medical Chemistry and Biochemistry, Molecular Medicine Center, Medical University of Sofia, Sofia, 2 Zdrave Str., 1431, Sofia, Bulgaria.
Hardev PandhaUniversity of Surrey, Guildford, GU2 7XH, Surrey, UK.
PRACTICAL consortium
Srilakshmi SrinivasanTranslational Research Institute, Brisbane, QLD, 4102, Australia.
Judith ClementsTranslational Research Institute, Brisbane, QLD, 4102, Australia.
Jyotsna BatraTranslational Research Institute, Brisbane, QLD, 4102, Australia.
Jong Y ParkDepartment of Cancer Epidemiology, Moffitt Cancer Center & Research Institute, Tampa, FL, 33612, USA.
Funding
Genetic & epigenetic analysis of angiogenesis genes in recurrent prostate cancerR01CA128813 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI PARK, JONG Y. · 2008 to 2012
$2.0MGene-Gene Interactions and Their Functional Roles in Prostate Cancer AggressivenessR21CA202417 · NCI · LSU HEALTH SCIENCES CENTER · PI LIN, HUI-YI · 2016 to 2017
$284kCancer Research UK 29017NCI NIH HHS R01 CA128813NCI NIH HHS R21 CA202417NIH HHS R01CA128813NIH HHS R21CA202417
Abstract
Risk classification for prostate cancer (PCa) aggressiveness and underlying mechanisms remain inadequate. Interactions between single nucleotide polymorphisms (SNPs) may provide a solution to fill these gaps. To identify SNP-SNP interactions in the four pathways (the angiogenesis-, mitochondria-, miRNA-, and androgen metabolism-related pathways) associated with PCa aggressiveness, we tested 8587 SNPs for 20,729 cases from the PCa consortium. We identified 3 KLK3 SNPs, and 1083 (P < 3.5 × 10
Indexed as
Biomarkers, TumorEpistasis, GeneticGenetic Predisposition to DiseaseGenotypeHumansKallikreinsMalePolymorphism, Single NucleotideProstate-Specific AntigenProstatic NeoplasmsBiomarkers, TumorKallikreinsKLK3 protein, humanProstate-Specific Antigen
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