Evidence map›Paper›PMID 33927182›Full record

ArticleTranslational psychiatry2021

Multiple dimensions of stress vs. genetic effects on depression.

Mark D Kvarta, Heather A Bruce, Joshua Chiappelli, Stephanie M Hare, Eric L Goldwaser, Jessica Sewell, Hemalatha Sampath, Samantha Lightner, Wyatt Marshall, Kathryn Hatch and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Mark D KvartaMaryland Psychiatric Research Center, Department of Psychiatry, , University of Maryland School of Medicine, Baltimore, MD, 21201, USA. mark.kvarta@som.umaryland.edu.ORCID 0000-0002-1093-1648
Heather A BruceMaryland Psychiatric Research Center, Department of Psychiatry, , University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Joshua ChiappelliMaryland Psychiatric Research Center, Department of Psychiatry, , University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Stephanie M HareMaryland Psychiatric Research Center, Department of Psychiatry, , University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Eric L GoldwaserMaryland Psychiatric Research Center, Department of Psychiatry, , University of Maryland School of Medicine, Baltimore, MD, 21201, USA.ORCID 0000-0002-9676-9230
Jessica SewellMaryland Psychiatric Research Center, Department of Psychiatry, , University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Hemalatha SampathMaryland Psychiatric Research Center, Department of Psychiatry, , University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Samantha LightnerMaryland Psychiatric Research Center, Department of Psychiatry, , University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Wyatt MarshallMaryland Psychiatric Research Center, Department of Psychiatry, , University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Kathryn HatchMaryland Psychiatric Research Center, Department of Psychiatry, , University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Elizabeth HumphriesInstitute for Genome Sciences, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Seth AmentMaryland Psychiatric Research Center, Department of Psychiatry, , University of Maryland School of Medicine, Baltimore, MD, 21201, USA.ORCID 0000-0001-6443-7509
Alan R ShuldinerDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Braxton D MitchellDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Francis J McMahonHuman Genetics Branch, National Institute of Mental Health Intramural Research Program, Bethesda, MD, 20892, USA.ORCID 0000-0002-9469-305X
Peter KochunovMaryland Psychiatric Research Center, Department of Psychiatry, , University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
L Elliot HongMaryland Psychiatric Research Center, Department of Psychiatry, , University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
University of Maryland, Baltimore · USNational Institute of Mental Health · US

Funding

Identification of Genes Involved in Major Mood DisordersZIAMH002843 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MCMAHON, FRANCIS J · 2009 to 2025
$24.5M
SOLAR-Eclipse Computational Tools for Imaging GeneticsR01EB015611 · NIBIB · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KOCHUNOV, PETER V. · 2012 to 2024
$5.0M
Redefine Trans-Neuropsychiatric Disorder Brain Patterns through Big-Data and Machine LearningRF1MH123163 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI KOCHUNOV, PETER V., THOMPSON, PAUL M · 2021 to 2021
$1.2M
Hybrid GPU/CPU Computing Resource to Support Connectomic and GenomicsS10OD023696 · OD · UNIVERSITY OF MARYLAND BALTIMORE · PI KOCHUNOV, PETER V. · 2018 to 2018
$593k
NIBIB NIH HHS R01 EB015611NIH HHS S10 OD023696NIMH NIH HHS RF1 MH123163
6 · The paper itself

Abstract

Many psychiatric disorders including depression involve complex interactions of genetics and environmental stressors. Environmental influence is challenging to measure objectively and account for in genetic studies because the necessary large population samples in these studies involve individuals with varying cultures and life experiences, clouding genetic findings. In a unique population with relative sociocultural homogeneity and a narrower range of types of stress experiences, we quantitatively assessed multiple stress dimensions and measured their potential influence in biasing the heritability estimate of depression. We quantified depressive symptoms, major lifetime stressors, current perceived stress, and a culturally specific community stress measure in individuals with depression-related diagnoses and community controls in Old Order Amish and Mennonite populations. Results showed that lifetime stressors measured by lifetime stressor inventory (R

Indexed as

DepressionMental DisordersHumansLife Change EventsPsychiatric Status Rating ScalesReproducibility of ResultsStress, Psychological

Identifiers

PMID33927182
PMCPMC8085217
OpenAlexW3158361803

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.