Evidence map›Paper›PMID 33927055›Full record

ArticleScience (New York, N.Y.)2021

Dynamic remodeling of host membranes by self-organizing bacterial effectors.

Ting-Sung Hsieh, Victor A Lopez, Miles H Black, Adam Osinski, Krzysztof Pawłowski, Diana R Tomchick, Jen Liou, Vincent S Tagliabracci

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Quantitative comparison of PI(3,5)PMolecular biology of the cell · 2026
    Article
  2. Histone modification cross talk between a host and pathogen.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Histone modification crosstalk between host and pathogen.bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Systematic Discovery of Novel Phosphoinositide-Binding Effectors inbioRxiv : the preprint server for biology · 2025
    Article
  7. Quantitative comparison of PI(3,5)PbioRxiv : the preprint server for biology · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Biochemical and structural insights into a 5' to 3' RNA ligase reveal a potential role in tRNA ligation.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  13. Article
  14. Nonlinear dynamics in phosphoinositide metabolism.Current opinion in cell biology · 2024
    Review
  15. Article
  16. Article
  17. Article
  18. Insights into the role of legionella effectors on host metabolic perturbations.Frontiers in cellular and infection microbiology · 2024
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ting-Sung Hsieh *Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0003-2792-0168
Victor A Lopez *Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0003-1618-5786
Miles H Black *Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-2864-1710
Adam OsinskiDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0003-0010-0733
Krzysztof PawłowskiDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-5367-0935
Diana R TomchickDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-7529-4643
Jen LiouDepartment of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0003-1546-3115
Vincent S TagliabracciDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. vincent.tagliabracci@utsouthwestern.edu.ORCID 0000-0002-9735-4678

Funding

DIVISION OF CELL &MOLECULAR BIOLOGY TRAINING PROGRAMT32GM008203 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI COBB, MELANIE H. · 1987 to 2018
$7.0M
Breathing life into dead enzymesDP2GM137419 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI TAGLIABRACCI, VINCENT SCOTT · 2019 to 2020
$2.6M
Functions and regulation of endoplasmic reticulum-plasma membrane junctionsR01GM113079 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI LIOU, JEN · 2016 to 2020
$1.6M
Single Crystal X-ray Diffractometer equipped with Hybrid Pixel Array Detector and In Situ Crystallization Plate Screening CapS10OD025018 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI TOMCHICK, DIANA R. · 2018 to 2018
$453k
TEM for UT Southwestern Electron Microscopy Core FacilityS10OD021685 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI LUBY-PHELPS, KATHERINE J · 2017 to 2017
$398k
Lipoprotein Phosphorylation by Secretory Pathway KinasesF30HL143859 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI BLACK, MILES HENRY · 2018 to 2021
$102k
NHLBI NIH HHS F30 HL143859NIGMS NIH HHS DP2 GM137419NIGMS NIH HHS R01 GM113079NIGMS NIH HHS T32 GM008203NIH HHS S10 OD021685NIH HHS S10 OD025018
6 · The paper itself

Abstract

During infection, intracellular bacterial pathogens translocate a variety of effectors into host cells that modify host membrane trafficking for their benefit. We found a self-organizing system consisting of a bacterial phosphoinositide kinase and its opposing phosphatase that formed spatiotemporal patterns, including traveling waves, to remodel host cellular membranes. The

Indexed as

AnimalsBacterial ProteinsChlorocebus aethiopsCOS CellsEndoplasmic ReticulumFeedback, PhysiologicalHeLa CellsHost-Pathogen InteractionsHumansIntracellular MembranesLegionella pneumophilaMiceMutationPhosphatidylinositol 3-KinasePhosphatidylinositol PhosphatesPhosphoric Monoester HydrolasesBacterial ProteinsPhosphatidylinositol 3-Kinasephosphatidylinositol-3-phosphatasephosphatidylinositol 3-phosphatePhosphatidylinositol PhosphatesPhosphoric Monoester Hydrolases

Identifiers

PMID33927055
PMCPMC8543759

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.