Evidence map›Paper›PMID 33927001›Full record

ArticleArchives of disease in childhood. Fetal and neonatal edition2021

Viability and thresholds for treatment of extremely preterm infants: survey of UK neonatal professionals.

Lydia Mietta Di Stefano, Katherine Wood, Helen Mactier, Sarah Elizabeth Bates, Dominic Wilkinson

Open access · hybridAbstract read
In one paragraph

Article in Archives of disease in childhood. Fetal and neonatal edition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.

  1. Singapore Neonatal Resuscitation Guidelines 2026.Singapore medical journal · 2026
    Guideline
  2. Guideline
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  5. Are guidelines needed? International perspectives on decision-making and practice variation in the care of extremely preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2026
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  6. Review
  7. Review
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  9. [Expert recommendations on antenatal counseling for extremely preterm infants].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025
    Article
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  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Lydia Mietta Di StefanoFaculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia.ORCID http://orcid.org/0000-0002-3537-9968
Katherine WoodNewborn Care, John Radcliffe Hospital, Oxford, UK.
Helen MactierNeonatology, Princess Royal Maternity Hospital, Glasgow, UK.ORCID http://orcid.org/0000-0001-6154-5758
Sarah Elizabeth BatesDepartment of Paediatrics and Neonatology, Great Western Hospitals NHS Foundation Trust, Swindon, UK.
Dominic WilkinsonNewborn Care, John Radcliffe Hospital, Oxford, UK dominic.wilkinson@philosophy.ox.ac.uk.ORCID http://orcid.org/0000-0003-3958-8633
John Radcliffe Hospital · GBGreat Western Hospital · GBMonash University · AUPrincess Royal Maternity Hospital · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

backgroundDecisions about treatments for extremely preterm infants (EPIs) born in the 'grey zone' of viability can be ethically complex. This 2020 survey aimed to determine views of UK neonatal staff about thresholds for treatment of EPIs given a recently revised national Framework for Practice from the British Association of Perinatal Medicine.

methodsThe online survey requested participants indicate the lowest gestation at which they would be willing to offer active treatment and the highest gestation at which they would withhold active treatment of an EPI at parental request (their lower and upper thresholds). Relative risks were used to compare respondents' views based on profession and neonatal unit designation. Further questions explored respondents' conceptual understanding of viability.

results336 respondents included 167 consultants, 127 registrars/fellows and 42 advanced neonatal nurse practitioners (ANNPs). Respondents reported a median grey zone for neonatal resuscitation between 22

conclusionCompared with previous studies, we found a shift in the reported lower threshold for resuscitation in the UK, with greater acceptance of active treatment for infants <23 weeks' gestation.

Indexed as

Gestational AgeInfant CareInfant, Extremely PrematurePalliative CareResuscitationAttitude of Health PersonnelClinical Decision-MakingFemaleFetal ViabilityHealth Care SurveysHumansInfant, NewbornIntensive Care Units, NeonatalMaleNeonatologistsNurses, Neonatalethicsneonatologypalliative careresuscitation

Identifiers

PMID33927001
PMCPMC8543207
OpenAlexW3157652106

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.