ArticleScience (New York, N.Y.)2021
Stepwise pathogenic evolution of
Open access · greenAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.
0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed
17.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
94 citing papers in PubMed, 149 citations in OpenAlex.
- A single nucleotide polymorphism collapses phase variation and drives short-sighted evolution of O-antigen inGut microbes · 2026Article
- Morphological plasticity facilitates lung adaptation and dynamic immune remodeling in Mycobacterium abscessus infection.iScience · 2026Article
- Phylogenetic distribution and longitudinal persistence of plasmids inMicrobial genomics · 2026Article
- Simulating the host niche: balancing complexity and control in the experimental evolution of antibiotic resistance and pathoadaptation.Microbiology (Reading, England) · 2026Review
- Bacillus thuringiensis pathogenicity islands encode regulatory circuits controlling insecticidal Cry toxin expression during vegetative growth.PLoS pathogens · 2026Article
- Epigenetic phase variation in the gut microbiome enhances bacterial adaptation.Cell host & microbe · 2026Article
- Sequence of Antibiotic Administration for the Treatment ofAntibiotics (Basel, Switzerland) · 2026Article
- Comparative genomics and molecular insights into smooth and rough clinical isolates ofMicrobial genomics · 2026Article
- Review
- From colonisation to chronicity: adaptation ofMicrobiology (Reading, England) · 2026Article
- Transcription Factor Promiscuity Drives Regulatory Rewiring and Evolvability in Gene Networks in Bacteria.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Construction of a Subcutaneous Fat Transplantation Model Infected with Mycobacterium.Current medicinal chemistry · 2026Article
- Global lineages of non-tuberculous mycobacteria in residential water samples from Germany.BMC microbiology · 2025Article
- Pathogenicity and virulence ofVirulence · 2025Review
- The Crosstalk BetweenCells · 2025Review
- Characterization of new mouse models of acute and chronicAntimicrobial agents and chemotherapy · 2025Article
- Genomic characterisation of recurrent Mycobacterium avium isolates from chronically infected patients reveals patterns of within-host evolution.Genome medicine · 2025Article
- Distinct lung microbiota community states are associated with pulmonary nontuberculous mycobacterial disease prognosis.BMC microbiology · 2025Article
- The role of colony morphotype in shaping gene essentiality inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Prophage-encoded methyltransferase drives adaptation of community-acquired methicillin-resistant Staphylococcus aureus.The Journal of clinical investigation · 2025Article
34 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
25 authors at 7 institutions in 2 countries.
Josephine M BryantMolecular Immunity Unit, University of Cambridge Department of Medicine, MRC Laboratory of Molecular Biology, Cambridge, UK.ORCID https://orcid.org/0000-0002-0149-5768
Karen P BrownMolecular Immunity Unit, University of Cambridge Department of Medicine, MRC Laboratory of Molecular Biology, Cambridge, UK.ORCID https://orcid.org/0000-0002-0387-5318
Sophie BurbaudMolecular Immunity Unit, University of Cambridge Department of Medicine, MRC Laboratory of Molecular Biology, Cambridge, UK.ORCID https://orcid.org/0000-0003-0013-5565
Isobel EverallMolecular Immunity Unit, University of Cambridge Department of Medicine, MRC Laboratory of Molecular Biology, Cambridge, UK.ORCID https://orcid.org/0000-0003-4983-1158
Juan M BelardinelliMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins CO, USA.ORCID https://orcid.org/0000-0003-1336-9141
Daniela Rodriguez-RinconMolecular Immunity Unit, University of Cambridge Department of Medicine, MRC Laboratory of Molecular Biology, Cambridge, UK.
Dorothy M GrogonoMolecular Immunity Unit, University of Cambridge Department of Medicine, MRC Laboratory of Molecular Biology, Cambridge, UK.ORCID https://orcid.org/0000-0002-3423-3158
Chelsea M PetersonMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins CO, USA.ORCID https://orcid.org/0000-0002-7167-5860
Deepshikha VermaMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins CO, USA.ORCID https://orcid.org/0000-0002-8549-6409
Ieuan E EvansMolecular Immunity Unit, University of Cambridge Department of Medicine, MRC Laboratory of Molecular Biology, Cambridge, UK.ORCID https://orcid.org/0000-0002-9669-0805
Christopher RuisMolecular Immunity Unit, University of Cambridge Department of Medicine, MRC Laboratory of Molecular Biology, Cambridge, UK.ORCID https://orcid.org/0000-0003-0977-5534
Aaron WeimannMolecular Immunity Unit, University of Cambridge Department of Medicine, MRC Laboratory of Molecular Biology, Cambridge, UK.ORCID https://orcid.org/0000-0003-4597-2471
Divya AroraMolecular Immunity Unit, University of Cambridge Department of Medicine, MRC Laboratory of Molecular Biology, Cambridge, UK.ORCID https://orcid.org/0000-0003-3225-1712
Sony MalhotraDepartment of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK.ORCID https://orcid.org/0000-0002-3165-9081
Bridget BannermanMolecular Immunity Unit, University of Cambridge Department of Medicine, MRC Laboratory of Molecular Biology, Cambridge, UK.ORCID https://orcid.org/0000-0002-5746-8283
Charlotte PassemarMolecular Immunity Unit, University of Cambridge Department of Medicine, MRC Laboratory of Molecular Biology, Cambridge, UK.ORCID https://orcid.org/0000-0003-4990-0758
Kerra TempletonQueen Elizabeth University Hospital, NHS Greater Glasgow & Clyde, Glasgow, Scotland, UK.ORCID https://orcid.org/0000-0002-1110-4097
Gordon MacGregorQueen Elizabeth University Hospital, NHS Greater Glasgow & Clyde, Glasgow, Scotland, UK.ORCID https://orcid.org/0000-0002-8455-3424
Kasim JiwaNewcastle University Translational and Clinical Research Institute and Institute of Transplantation, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Andrew J FisherNewcastle University Translational and Clinical Research Institute and Institute of Transplantation, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.ORCID https://orcid.org/0000-0003-4822-7223
Tom L BlundellDepartment of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK.ORCID https://orcid.org/0000-0002-2708-8992
Diane J OrdwayMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins CO, USA.ORCID https://orcid.org/0000-0003-0003-326X
Mary JacksonMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins CO, USA.ORCID https://orcid.org/0000-0002-9212-0258
Julian ParkhillWellcome Sanger Institute, Hinxton, UK. arf27@cam.ac.uk jp369@cam.ac.uk.ORCID https://orcid.org/0000-0002-7069-5958
R Andres FlotoMolecular Immunity Unit, University of Cambridge Department of Medicine, MRC Laboratory of Molecular Biology, Cambridge, UK. arf27@cam.ac.uk jp369@cam.ac.uk.ORCID https://orcid.org/0000-0002-2188-5659
MRC Laboratory of Molecular Biology · GBColorado State University · USUniversity of Ulster · GBNewcastle upon Tyne Hospitals NHS Foundation Trust · GBQueen Elizabeth University Hospital · GBUniversity of Cambridge · GBScience and Technology Facilities Council · GB
Funding
Wellcome Trust 098051Wellcome Trust 107032Wellcome Trust 110224
Abstract
Although almost all mycobacterial species are saprophytic environmental organisms, a few, such as
Indexed as
Evolution, MolecularGenetic FitnessCommunicable Diseases, EmergingDatasets as TopicEpigenesis, GeneticGene Transfer, HorizontalGenome, BacterialHumansLungMutationMycobacterium abscessusMycobacterium Infections, NontuberculousPneumonia, BacterialVirulence
Identifiers
What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.