Evidence map›Paper›PMID 33926710›Full record

ReviewESMO open2021

Adolescents and young adults (AYA) with cancer: a position paper from the AYA Working Group of the European Society for Medical Oncology (ESMO) and the European Society for Paediatric Oncology (SIOPE).

A Ferrari, D Stark, F A Peccatori, L Fern, V Laurence, N Gaspar, I Bozovic-Spasojevic, O Smith, J De Munter, K Derwich and 9 more

Registry-linked trialOpen access · goldAbstract readReviewConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Review in ESMO open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06594510 (AYANDRA Study), which is not on this map. Cited by 157 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
157citing papers in PubMed, 8 pooled it
51.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06594510 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

AYANDRA Study: Addressing Youth and Adolescent Needs in Development, Research, and Advocacy

TypeobservationalSponsorFondazione Policlinico Universitario Agostino Gemelli IRCCSRan2025 to 2026Enrolled580ConditionsAYA Cancer Patients, AYA Cancer Survivors
3 · Its place in the literature

Who cites it

157 citing papers in PubMed, 8 syntheses or guidelines pooled it, 247 citations in OpenAlex.

  1. Health-related quality of life domains relevant to people in Europe undergoing cancer treatment: a systematic review of qualitative research.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026
    Pooled it
  2. Needs and health-related quality of life domains relevant to people in Europe with advanced cancer in need of palliative care: a systematic review of qualitative research.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026
    Pooled it
  3. Systematic review of the needs and health-related quality of life domains relevant to people surviving cancer in Europe.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
    Pooled it
  4. Pooled it
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  7. Using consumer engagement strategies to improve healthcare safety for young people: An exploration of the relevance and suitability of current approaches.Health expectations : an international journal of public participation in health care and health policy · 2022
    Pooled it
  8. Pooled it
  9. Trial
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  15. Bridging pediatric and adult neuro-oncology: Insights into adolescents and young adults (AYA) central nervous system tumors.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Review
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97 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 17 institutions in 12 countries.

A FerrariPediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy. Electronic address: education@esmo.orgss.
D StarkLeeds Institute of Medical Research, School of Medicine University of Leeds, Leeds, UK. Electronic address: education@esmo.orgsss.
F A PeccatoriGynecologic Oncology Department, European Institute of Oncology IRCCS, Milan, Italy.
L FernDepartment of Oncology, University College London Hospitals NHS Foundation Trust, London, UK.
V LaurenceMedical Oncology Department and SIREDO Oncology Center (Care, Innovation and Research for Children and AYA with Cancer), Institut Curie, Paris, France.
N GasparDepartment of Oncology for Child and Adolescent, Gustave Roussy Cancer Campus, Villejuif, France.
I Bozovic-SpasojevicMedical Oncology Department, Institute for Oncology and Radiology of Serbia, Belgrade, Republic of Serbia.
O SmithNational Children's Cancer Service, Children's Health Ireland at Crumlin and Systems Biology Ireland, University College Dublin, Dublin, Ireland.
J De MunterUniversity Hospital Ghent Cancer Center, UZ Gent, Ghent, Belgium.
K DerwichDepartment of Pediatric Oncology, Hematology and Transplantology, Poznan University of Medical Sciences, Poznan, Poland.
L HjorthLund University, Skane University Hospital, Department of Clinical Sciences Lund, Pediatrics, Lund, Sweden.
W T A van der GraafDepartment of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
L SoanesTeenage Cancer Trust, London, UK.
S JezdicScientific and Medical Division, European Society for Medical Oncology (ESMO), Lugano, Switzerland.
A BlondeelDepartment of Scientific Programme Coordination, European Society for Paediatric Oncology (SIOPE), Brussels, Belgium.
S BielackZentrum für Kinder, Jugend und Frauenmedizin Pädiatrie 5, KlinikumStuttgart - Olgahospital, Stuttgart, Germany.
J-Y DouillardScientific and Medical Division, European Society for Medical Oncology (ESMO), Lugano, Switzerland.
G Mountzios2nd Department of Medical Oncology and Clinical Trial Unit, Henry Dunant Hospital, Athens, Greece.
E SaloustrosDepartment of Oncology, University Hospital of Larissa, Larissa, Greece.
European Society for Medical Oncology · CHEuropean Institute of Oncology · ITEuropean Society for Paediatric Oncology · BEFondazione IRCCS Istituto Nazionale dei Tumori · ITGhent University Hospital · BEHenry Dunant Hospital · GRInstitut Curie · FRInstitut Gustave Roussy · FRLund University · SEOlgahospital · DEOncology Institute of Vojvodina · RSPoznan University of Medical Sciences · PLThe Netherlands Cancer Institute · NLUniversity College Dublin · IEUniversity College London Hospitals NHS Foundation Trust · GBUniversity Hospital of Larissa · GRUniversity of Leeds · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is well recognised that adolescents and young adults (AYA) with cancer have inequitable access to oncology services that provide expert cancer care and consider their unique needs. Subsequently, survival gains in this patient population have improved only modestly compared with older adults and children with cancer. In 2015, the European Society for Medical Oncology (ESMO) and the European Society for Paediatric Oncology (SIOPE) established the joint Cancer in AYA Working Group in order to increase awareness among adult and paediatric oncology communities, enhance knowledge on specific issues in AYA and ultimately improve the standard of care for AYA with cancer across Europe. This manuscript reflects the position of this working group regarding current AYA cancer care, the challenges to be addressed and possible solutions. Key challenges include the lack of specific biological understanding of AYA cancers, the lack of access to specialised centres with age-appropriate multidisciplinary care and the lack of available clinical trials with novel therapeutics. Key recommendations include diversifying interprofessional cooperation in AYA care and specific measures to improve trial accrual, including centralising care where that is the best means to achieve trial accrual. This defines a common vision that can lead to improved outcomes for AYA with cancer in Europe.

Indexed as

Medical OncologyNeoplasmsAdolescentChildEuropeHumansPractice Guidelines as TopicYoung Adultadolescents and young adultscancerclinical trialseducationinterdisciplinary

Identifiers

PMID33926710
PMCPMC8103533
OpenAlexW3146007858

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.