Evidence map›Paper›PMID 33926706›Full record

ArticleSurgery2021

Machine learning for the prediction of pathologic pneumatosis intestinalis.

Kadie Clancy, Esmaeel Reza Dadashzadeh, Robert Handzel, Caroline Rieser, J B Moses, Lauren Rosenblum, Shandong Wu

Abstract read
In one paragraph

Article in Surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kadie ClancyDepartment of Computer Science, University of Pittsburgh, PA.
Esmaeel Reza DadashzadehDepartment of Surgery, University of Pittsburgh Medical Center, PA.
Robert HandzelDepartment of Surgery, University of Pittsburgh Medical Center, PA.
Caroline RieserDepartment of Surgery, University of Pittsburgh Medical Center, PA.
J B MosesDepartment of Surgery, University of Pittsburgh Medical Center, PA.
Lauren RosenblumDepartment of Surgery, University of Pittsburgh Medical Center, PA.
Shandong WuDepartments of Radiology, Biomedical Informatics, and Bioengineering, University of Pittsburgh, PA. Electronic address: wus3@upmc.edu.

Funding

Vascular Surgery Research Training (VascTrain) ProgramT32HL098036 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Edith Tzeng · 2010 to 2026
$7.2M
Postdoctoral Research Training in Biotherapy of CancerT32CA113263 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Udai S Kammula · 2006 to 2026
$3.6M
Quantitative assessment of breast MRIs for breast cancer risk predictionR01CA193603 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WU, SHANDONG · 2015 to 2018
$1.7M
Deep interpretation of mammographic images in breast cancer screeningR01CA218405 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WU, SHANDONG · 2018 to 2021
$1.4M
NCI NIH HHS R01 CA193603NCI NIH HHS R01 CA218405NCI NIH HHS T32 CA113263NHLBI NIH HHS T32 HL098036
6 · The paper itself

Abstract

backgroundThe radiographic finding of pneumatosis intestinalis can indicate a spectrum of underlying processes ranging from a benign finding to a life-threatening condition. Although radiographic pneumatosis intestinalis is relatively common, there is no validated clinical tool to guide surgical management.

methodsUsing a retrospective cohort of 300 pneumatosis intestinalis cases from a single institution, we developed 3 machine learning models for 2 clinical tasks: (1) the distinction of benign from pathologic pneumatosis intestinalis cases and (2) the determination of patients who would benefit from an operation. The 3 models are (1) an imaging model based on radiomic features extracted from computed tomography scans, (2) a clinical model based on clinical variables, and (3) a combination model using both the imaging and clinical variables.

resultsThe combination model achieves an area under the curve of 0.91 (confidence interval: 0.87-0.94) for task I and an area under the curve of 0.84 (confidence interval: 0.79-0.88) for task II. The combination model significantly (P < .05) outperforms the imaging model and the clinical model for both tasks. The imaging model achieves an area under the curve of 0.72 (confidence interval: 0.57-0.87) for task I and 0.68 (confidence interval: 0.61-0.74) for task II. The clinical model achieves an area under the curve of 0.87 (confidence interval: 0.83-0.91) for task I and 0.76 (confidence interval: 0.70-0.81) for task II.

conclusionThis study suggests that combined radiographic and clinical features can identify pathologic pneumatosis intestinalis and aid in patient selection for surgery. This tool may better inform the surgical decision-making process for patients with pneumatosis intestinalis.

Indexed as

Machine LearningAgedFemaleHumansMaleMiddle AgedModels, StatisticalPneumatosis Cystoides IntestinalisReproducibility of ResultsRetrospective StudiesROC CurveTomography, X-Ray Computed

Identifiers

PMID33926706
PMCPMC8405549

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.