Evidence map›Paper›PMID 33926555›Full record

ArticleStem cell research & therapy2021

Human acellular amniotic membrane incorporating exosomes from adipose-derived mesenchymal stem cells promotes diabetic wound healing.

Shune Xiao, Chunfang Xiao, Yong Miao, Jin Wang, Ruosi Chen, Zhexiang Fan, Zhiqi Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shune Xiao *Department of Plastic Surgery, Nan Fang Hospital, Southern Medical University, Guangzhou Da Dao Bei 1838, Guangzhou, 510515, China.
Chunfang Xiao *Department of Obstetrics and Gynecology, Nan Fang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Yong MiaoDepartment of Plastic Surgery, Nan Fang Hospital, Southern Medical University, Guangzhou Da Dao Bei 1838, Guangzhou, 510515, China.
Jin WangDepartment of Plastic Surgery, Nan Fang Hospital, Southern Medical University, Guangzhou Da Dao Bei 1838, Guangzhou, 510515, China.
Ruosi ChenDepartment of Plastic Surgery, Nan Fang Hospital, Southern Medical University, Guangzhou Da Dao Bei 1838, Guangzhou, 510515, China.
Zhexiang FanDepartment of Plastic Surgery, Nan Fang Hospital, Southern Medical University, Guangzhou Da Dao Bei 1838, Guangzhou, 510515, China.
Zhiqi HuDepartment of Plastic Surgery, Nan Fang Hospital, Southern Medical University, Guangzhou Da Dao Bei 1838, Guangzhou, 510515, China. huzhiqidr163@i.smu.edu.cn.ORCID 0000-0002-1657-0396

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiabetic wounds threaten the health and quality of life of patients and their treatment remains challenging. ADSC-derived exosomes have shown encouraging results in enhancing diabetic wound healing. However, how to use exosomes in wound treatment effectively is a problem that needs to be addressed at present.

methodsA diabetic mouse skin wound model was established. ADSC-derived exosomes (ADSC-Exos) were isolated, and in vitro application of exosomes was evaluated using human umbilical vein endothelial cells (HUVECs) and human dermal fibroblasts (HDFs). After preparation and characterization of a scaffold of human acellular amniotic membrane (hAAM) loaded with ADSC-Exos in vitro, they were transplanted into wounds in vivo and wound healing phenomena were observed by histological and immunohistochemical analyses to identify the wound healing mechanism of the exosome-hAAM composites.

resultsThe hAAM scaffold dressing was very suitable for the delivery of exosomes. ADSC-Exos enhanced the proliferation and migration of HDFs and promoted proliferation and tube formation of HUVECs in vitro. In vivo results from a diabetic skin wound model showed that the hAAM-Exos dressing accelerated wound healing by regulating inflammation, stimulating vascularization, and promoting the production of extracellular matrix.

conclusionExosome-incorporated hAAM scaffolds showed great potential in promoting diabetic skin wound healing, while also providing strong evidence for the future clinical applications of ADSC-derived exosomes.

Indexed as

Diabetes MellitusExosomesMesenchymal Stem CellsAmnionCell ProliferationHumansQuality of LifeWound HealingAcellular amniotic membraneAdipose-derived mesenchymal stem cellsDiabetic wound healingExosomes

Identifiers

PMID33926555
PMCPMC8082232

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.