ArticleClinical epigenetics2021
Characteristics of epigenetic aging across gestational and perinatal tissues.
Article in Clinical epigenetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- A meta-analysis of pre-pregnancy maternal body mass index and placental DNA methylation identifies 27 CpG sites with implications for mother-child health.Communications biology · 2022Pooled it
- Characterizing placental dysfunction with DNA methylation profiling and placental histopathology.Placenta · 2026Article
- Donor age and sex program MSC secretome signaling: a quadrant framework for precision therapy.Stem cell research & therapy · 2026Article
- Analysis of prenatal medication use and placental epigenetic gestational age in extremely low gestational age newborns (ELGANs) highlight relationships to aspirin use during pregnancy.Clinical epigenetics · 2025Article
- Placental epigenetic age and adolescent blood pressure: the Extremely Low Gestational Age Newborn cohort.Pediatric research · 2025Article
- Article
- Placental epigenetic clocks derived from crowdsourcing: Implications for the study of accelerated aging in obstetrics.iScience · 2025Article
- Epigenomic signatures of accelerated epigenetic aging are associated with congenital heart disease in newborns.BMC medical genomics · 2025Article
- The association of prenatal ambient air pollution with placental epigenetic gestational age at birth.Environmental epidemiology (Philadelphia, Pa.) · 2025Article
- Sex-specific effects of in utero exposure to per- and polyfluoroalkyl substances on placental development.Environmental research · 2025Article
- Article
- Adiponectin and Glucocorticoids Modulate Risk for Preterm Birth: The Healthy Start Study.The Journal of clinical endocrinology and metabolism · 2025Article
- Maternal Adverse Childhood Experiences and Biological Aging During Pregnancy and in Newborns.JAMA network open · 2024Article
- Prenatal stress and gestational epigenetic age: No evidence of associations based on a large prospective multi-cohort study.Research square · 2024Article
- Prenatal Maternal Occupation and Child Epigenetic Age Acceleration in an Agricultural Region: NIMHD Social Epigenomics Program.JAMA network open · 2024Article
- Consistent cord blood DNA methylation signatures of gestational age between South Asian and white European cohorts.Clinical epigenetics · 2024Article
- Sex differences in DNA methylation across gestation: a large scale, cross-cohort, multi-tissue analysis.Cellular and molecular life sciences : CMLS · 2024Article
- Evidence of reduced gestational age in response to in utero arsenic exposure and implications for aging trajectories of the newborn.Environment international · 2024Article
- Epigenetics of prenatal stress in humans: the current research landscape.Clinical epigenetics · 2024Review
- Associations of green and blue space exposure in pregnancy with epigenetic gestational age acceleration.Epigenetics · 2023Article
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 7 countries.
Funding
Abstract
backgroundEpigenetic clocks have been used to indicate differences in biological states between individuals of same chronological age. However, so far, only few studies have examined epigenetic aging in newborns-especially regarding different gestational or perinatal tissues. In this study, we investigated which birth- and pregnancy-related variables are most important in predicting gestational epigenetic age acceleration or deceleration (i.e., the deviation between gestational epigenetic age estimated from the DNA methylome and chronological gestational age) in chorionic villus, placenta and cord blood tissues from two independent study cohorts (ITU, n = 639 and PREDO, n = 966). We further characterized the correspondence of epigenetic age deviations between these tissues.
resultsAmong the most predictive factors of epigenetic age deviations in single tissues were child sex, birth length, maternal smoking during pregnancy, maternal mental disorders until childbirth, delivery mode and parity. However, the specific factors related to epigenetic age deviation and the direction of association differed across tissues. In individuals with samples available from more than one tissue, relative epigenetic age deviations were not correlated across tissues.
conclusionGestational epigenetic age acceleration or deceleration was not related to more favorable or unfavorable factors in one direction in the investigated tissues, and the relative epigenetic age differed between tissues of the same person. This indicates that epigenetic age deviations associate with distinct, tissue specific, factors during the gestational and perinatal period. Our findings suggest that the epigenetic age of the newborn should be seen as a characteristic of a specific tissue, and less as a general characteristic of the child itself.
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