ArticleWorld journal of surgical oncology2021
Identification of a ferroptosis-related gene signature predictive model in colon cancer.
Article in World journal of surgical oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Multi-omics integration and machine learning-driven construction of an immunogenic cell death prognostic model for colon cancer and functional validation of FCGR2A.Frontiers in pharmacology · 2025Article
- Promising roles of vitamin D receptor and APRO family proteins for the development of cancer stem cells targeted malignant tumor therapy.Oncology research · 2025Review
- Identification of lncRNA-mRNA network linking ferroptosis and immune infiltration to colon adenocarcinoma suppression.Heliyon · 2024Article
- Article
- Insights on Ferroptosis and Colorectal Cancer: Progress and Updates.Molecules (Basel, Switzerland) · 2022Review
- Non-Canonical Programmed Cell Death in Colon Cancer.Cancers · 2022Review
- Ferroptosis-related long non-coding RNA signature predicts the prognosis of hepatocellular carcinoma.Aging · 2022Article
- Prediction of overall survival based upon a new ferroptosis-related gene signature in patients with clear cell renal cell carcinoma.World journal of surgical oncology · 2022Article
- Predictive role of ferroptosis-related long non-coding RNAs in bladder cancer and their association with immune microenvironment and immunotherapy response.World journal of surgical oncology · 2022Article
- Identification of a novel cellular senescence-related signature for the prediction of prognosis and immunotherapy response in colon cancer.Frontiers in genetics · 2022Article
- Ferroptosis: Reviewing CRC with the Third Eye.Journal of inflammation research · 2022Review
- Identification and validation of a novel ferroptosis-related gene signature for prognosis and potential therapeutic target prediction in cholangiocarcinoma.Frontiers in immunology · 2022Article
- Circ_0026416 downregulation blocks the development of colorectal cancer through depleting MYO6 expression by enriching miR-545-3p.World journal of surgical oncology · 2021Article
- Establishment of a novel ferroptosis-related lncRNA pair prognostic model in colon adenocarcinoma.Aging · 2021Article
- Importance of Circ0009910 in colorectal cancer pathogenesis as a possible regulator of miR-145 and PEAK1.World journal of surgical oncology · 2021Article
- Ferroptosis-related gene signature predicts the prognosis in Oral squamous cell carcinoma patients.BMC cancer · 2021Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe prognosis of colon cancer (CC) is challenging to predict due to its highly heterogeneous nature. Ferroptosis, an iron-dependent form of cell death, has roles in various cancers; however, the correlation between ferroptosis-related genes (FRGs) and prognosis in CC remains unclear.
methodsThe expression profiles of FRGs and relevant clinical information were retrieved from the Cancer Genome Atlas (TCGA) database. Cox regression analysis and the least absolute shrinkage and selection operator (LASSO) regression model were performed to build a prognostic model in TCGA cohort.
resultsTen FRGs, five of which had mutation rates ≥ 3%, were found to be related to the overall survival (OS) of patients with CC. Patients were divided into high- and low-risk groups based on the results of Cox regression and LASSO analysis. Patients in the low-risk group had a significantly longer survival time than patients in the high-risk group (P < 0.001). Enrichment analyses in different risk groups showed that the altered genes were associated with the extracellular matrix, fatty acid metabolism, and peroxisome. Age, risk score, T stage, N stage, and M stage were independent predictors of patient OS based on the results of Cox analysis. Finally, a nomogram was constructed to predict 1-, 3-, and 5-year OS of patients with CC based on the above five independent factors.
conclusionA novel FRG model can be used for prognostic prediction in CC and may be helpful for individualized treatment.
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