SynthesisBMC pediatrics2021
Effectiveness of interventions on early neurodevelopment of preterm infants: a systematic review and meta-analysis.
Synthesis in BMC pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 50 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of Home Based Early Intervention of Extremely Premature Infant by Parent
Combining Neonatal Neurobehavioral (Brazelton) And Motor Behavior (Prechtl) In The Assessment And Ultra Early Physical Therapy Intervention Of Premature Infants
Who cites it
50 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Multisensory stimulation for promoting development and preventing morbidity in preterm infants.The Cochrane database of systematic reviews · 2026Pooled it
- Vestibular stimulation for promoting development and preventing morbidity in preterm infants.The Cochrane database of systematic reviews · 2026Pooled it
- Olfactory stimulation for promoting development and preventing morbidity in preterm infants.The Cochrane database of systematic reviews · 2026Pooled it
- Parents' experiences of psychotherapeutic support on the neonatal unit: A mixed methods systematic review to inform intervention development for a multicultural population.Nursing in critical care · 2025Pooled it
- Neuropsychiatric Outcomes in Children and Adolescents With Perinatally Acquired HIV: A Systematic Review and Meta-Analysis.Journal of acquired immune deficiency syndromes (1999) · 2025Pooled it
- Musical and vocal interventions to improve neurodevelopmental outcomes for preterm infants.The Cochrane database of systematic reviews · 2023Pooled it
- Associations of Mitochondrial Function, Stress, and Neurodevelopmental Outcomes in Early Life: A Systematic Review.Developmental neuroscience · 2022Pooled it
- Effect of physical therapy on bone remodelling in preterm infants: a multicenter randomized controlled clinical trial.BMC pediatrics · 2022Trial
- Life after the NICU: targeting modifiable factors to improve neurodevelopmental outcomes in children born extremely preterm.Pediatric research · 2026Review
- Gestational Selenium Exposure and Neonatal Health Outcomes: A Systematic Review of Mortality, Morbidity, and Neurobehavioral Development.Journal of clinical medicine · 2026Review
- Early Nutrition as a Modulator of Neurodevelopment via the Gut Microbiota in Preterm Neonates.Children (Basel, Switzerland) · 2026Review
- Gestational age and neurodevelopmental outcomes from 1 to 5 years: the PERSIAN birth cohort.Pediatric research · 2026Article
- Neuromotor and Cognitive Outcomes of Preterm Infants at 3 Months of Corrected Age in a Northeastern Region of Brazil: Longitudinal Feasibility Study.JMIR formative research · 2026Article
- Risk factors for developmental delays in small for gestational age children at age of 24-36 months.European child & adolescent psychiatry · 2026Article
- Practice-informed barriers and contextual solutions in neonatal habilitation across Indian Neonatal Intensive Care Units: A qualitative exploration of therapists' perspectives.BMC pediatrics · 2026Article
- General movement based therapy to support neurodevelopment of preterm infants: a randomized clinical trial.Pediatric research · 2026Article
- Effects of multisensory interventions initiated during NICU hospitalization on neurodevelopment in preterm infants: a systematic review and meta-analysis.Frontiers in pediatrics · 2026Review
- Analysis of influencing factors for language development delay with comorbid intellectual disability in children and investigation of the effects of early neurobehavioral intervention.American journal of translational research · 2026Article
- Stress during the first 1,000 days of life in humans, when everything begins.Frontiers in human neuroscience · 2026Review
- The influence of family care guidance for premature infants based on a telemedicine model on their neurodevelopmental assessment indicators.Frontiers in pediatrics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAs preterm infants' neurodevelopment is shaped by NICU-related factors during their hospitalization, it is essential to evaluate which interventions are more beneficial for their neurodevelopment at this specific time. The objective of this systematic review and meta-analysis was to evaluate the effectiveness of interventions initiated during NICU hospitalization on preterm infants' early neurodevelopment during their hospitalization and up to two weeks corrected age (CA).
methodsThis systematic review referred to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses [PRISMA] guidelines and was registered in PROSPERO (CRD42017047072). We searched CINAHL, MEDLINE, PubMed, EMBASE (OVID), Cochrane Systematic Reviews, CENTRAL, and Web of Science from 2002 to February 2020 and included randomized controlled/clinical trials conducted with preterm infants born between 24 and 36
resultsFindings of 12 studies involving 901 preterm infants were synthesized. We combined three studies in a meta-analysis showing that compared to standard care, the NIDCAP intervention is effective in improving preterm infants' neurobehavioral and neurological development at two weeks CA. We also combined two other studies in a meta-analysis indicating that parental participation did not significantly improve preterm infants' neurobehavioral development during NICU hospitalization. For all other interventions (i.e., developmental care, sensory stimulation, music and physical therapy), the synthesis of results shows that compared to standard care or other types of comparators, the effectiveness was either controversial or partially effective.
conclusionsThe overall quality of evidence was rated low to very low. Future studies are needed to identify interventions that are the most effective in promoting preterm infants' early neurodevelopment during NICU hospitalization or close to term age. Interventions should be appropriately designed to allow comparison with previous studies and a combination of different instruments could provide a more global assessment of preterm infants' neurodevelopment and thus allow for comparisons across studies.
trial registrationProspero CRD42017047072 .
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.