ArticleCancer control : journal of the Moffitt Cancer Center
The Early Diagnostic Value of Serum Interleukin-8 in Esophagogastric Junction Adenocarcinoma.
Article in Cancer control : journal of the Moffitt Cancer Center. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Interleukin-8 in health and disease.Molecular biomedicine · 2026Review
- Value of exhaled hydrogen sulfide in early diagnosis of esophagogastric junction adenocarcinoma.Oncology letters · 2024Article
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Authors and funding
10 authors.
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Abstract
backgroundEsophagogastric junction adenocarcinoma (EJA) is one of the most common malignant tumors of digestive tract with high mortality worldwide. Given a lack of early diagnosis biomarkers, the prognosis of EJA is poor. Non-invasive biomarkers for early-stage EJA are urgently required.
objectiveWe aimed at evaluating the early diagnostic value of serum interleukin-8 (IL-8) level in EJA patients.
methodsThe IL-8 mRNA expression data were analyzed based on the stomach cardia adenocarcinoma samples of The Cancer Genome Atlas (TCGA) database. Enzyme-linked immunosorbent assay (ELISA) was used to measure the concentration of serum IL-8 in 95 EJA patients and 95 normal controls enrolled from 2 different cancer hospitals. The diagnostic accuracy of serum IL-8 was evaluated by applying Mann-Whitney
resultsThe mRNA expression levels and serum levels of IL-8 in EJA group were significantly higher than those in the normal group (all
conclusionsSerum IL-8 represents a potential diagnostic biomarker to identify early-stage EJA.
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