ArticleExperimental biology and medicine (Maywood, N.J.)2021
New insights into hallux valgus by whole exome sequencing study.
Article in Experimental biology and medicine (Maywood, N.J.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Combining Mendelian Randomization and Experimental Validation to Reveal the Causal Relationship Between Hallux Valgus and Serum Metabolites and to Identify Their Therapeutic Targets and Relevant Components.Food science & nutrition · 2026Article
- Factors Related to the Etiology of Hallux Abducto Valgus: A Systematic Review.Journal of functional morphology and kinesiology · 2026Review
- Advances in the Causes and Treatment of Floating Toes after the Weil Osteotomy: A Scoping Review.Orthopaedic surgery · 2024Article
- Identification of copy number variants contributing to hallux valgus.Frontiers in genetics · 2023Article
- Impacts of Methylenetetrahydrofolate Reductase Genotypes on Hallux Valgus.In vivo (Athens, Greece)Article
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The traditional view is that the occurrence and development of hallux valgus (HV) are mainly due to environmental factors. Recent studies have suggested the large contribution of genetic heritability to HV, but it remains elusive about the genetic variants underlying the development of HV. To gain knowledge about the molecular mechanisms of HV pathogenesis by genetic approach, whole exome sequencing studies were performed in 10 individuals (7 affected by HV and 3 unaffected) from three independent families. Specific mutations were found to be related to the pathogenesis of HV and conform to the laws of inheritance. A total of 36 genes with functional candidate single nucleotide variants were identified. Genetic predisposition plays an important role in the development of HV. Interestingly, some of these genes are related to chronic arthritis, such as the complement encoding gene
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