Evidence map›Paper›PMID 33926248›Full record

ArticleEpilepsy currents2021

Stimulating Solutions for Intractable Epilepsy.

Timothy Denison, Mohamad Koubeissi, Esther Krook-Magnuson, David Mogul, Gregory Worrell, Catherine Schevon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsy currents, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Towards network-guided neuromodulation for epilepsy.Brain : a journal of neurology · 2022
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Timothy DenisonInstitute of Biomedical Engineering and MRC Brain Network Dynamics Unit, 6396University of Oxford, Northern Ireland, United Kingdom.
Mohamad KoubeissiDepartment of Neurology, George Washington University, Washington, DC, USA.
Esther Krook-MagnusonDepartment of Biomedical Engineering, 5635University of Minnesota, Minneapolis, MN, USA.ORCID https://orcid.org/0000-0002-6119-0165
David MogulDepartment of Biomedical Engineering, 2455Illinois Institute of Technology, Chicago, IL, USA.
Gregory WorrellDepartment of Neurology, 4352Mayo Clinic, Rochester, MN, USA.
Catherine SchevonDepartment of Neurology, 5798Columbia University, New York City, NY, USA.ORCID https://orcid.org/0000-0002-4485-7933

Funding

Seizure localization in humans: the effect of inhibitory surround on the EEGR01NS084142 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SCHEVON, CATHERINE A · 2013 to 2022
$6.0M
Hippobellum: Cerebellar influence on the hippocampus and temporal lobe seizuresR01NS112518 · NINDS · UNIVERSITY OF MINNESOTA · PI Esther Krook-Magnuson · 2020 to 2026
$3.4M
Neurophysiologically Based Brain State Tracking & Modulation in Focal EpilepsyUH3NS095495 · NINDS · MAYO CLINIC ROCHESTER · PI WORRELL, GREGORY A · 2019 to 2021
$2.8M
Understanding the Fast and Slow Spatiotemporal Dynamics of Human SeizuresR01NS110669 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI CASH, SYDNEY S, EDEN, URI TZVI · 2019 to 2023
$2.3M
A novel inhibitory target for temporal lobe epilepsyR01NS104071 · NINDS · UNIVERSITY OF MINNESOTA · PI KROOK-MAGNUSON, ESTHER · 2018 to 2022
$1.6M
Manipulating multisite endogenous brain rhythms disrupts epileptic seizuresR01NS092760 · NINDS · ILLINOIS INSTITUTE OF TECHNOLOGY · PI MOGUL, DAVID J · 2016 to 2020
$1.3M
NINDS NIH HHS R01 NS084142NINDS NIH HHS R01 NS092760NINDS NIH HHS R01 NS104071NINDS NIH HHS R01 NS110669NINDS NIH HHS R01 NS112518NINDS NIH HHS UH3 NS095495
6 · The paper itself

Abstract

Implantable devices for controlling medically intractable seizures nondestructively are rapidly advancing. These offer reversible, potentially, restorative options beyond traditional, surgical procedures, which rely, largely on resection or ablation of selected brain sites. Several lines of, investigation aimed at improving efficacy of these devices are discussed, ranging from identifying novel subcortical, white matter, or cell-type specific targets to engineering advances for adaptive techniques based- on continuous, dynamic system analysis.

Indexed as

electrical stimulationepileptic networksintractable epilepsynext-generation devicestherapeutic devices

Identifiers

PMID33926248
PMCPMC8655249

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.