ArticleCirculation2021
Spending on Cardiovascular Disease and Cardiovascular Risk Factors in the United States: 1996 to 2016.
Article in Circulation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
81 citing papers in PubMed, 2 syntheses or guidelines pooled it, 148 citations in OpenAlex.
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- International Systematic Review of Utility Values Associated with Cardiovascular Disease and Reflections on Selecting Evidence for a UK Decision-Analytic Model.Medical decision making : an international journal of the Society for Medical Decision Making · 2024Pooled it
- The cost-effectiveness of peer education on medication adherence in the elderly with hypertension: a randomized controlled trial.BMC public health · 2024Trial
- Reproducibility of Published Randomized Controlled Trial Results in Cardiovascular Surgery: Protocol for a Meta-Epidemiological Umbrella Review.JMIR research protocols · 2026Article
- Program cost and return on investment analysis of remote patient monitoring for hypertension management in the cardiology department of a large healthcare system.Journal of telemedicine and telecare · 2026Article
- Data sharing statements: impact of journal policies across clinical research disciplines.European heart journal · 2026Article
- Assessing Supply, Demand, and Adequacy of Cardiologists in the United States: Projecting a National Shortage.Journal of the American Heart Association · 2026Article
- Patient-clinician communication and cardiovascular outcomes: An analysis of the hispanic community health study/study of latinos (HCHS/SOL), 2008-2019.American journal of preventive cardiology · 2026Article
- Factors affecting cost-related medication non-adherence among US population with cardiovascular risk factors.Primary health care research & development · 2026Article
- Association of novel lipid markers with cardiovascular and cerebrovascular disease risk: A cross-sectional NHANES 1999 to 2018 study.Medicine · 2026Article
- 13-HODE and 13-HOTrE, Present in the Traditional Chinese Medicine Herbal Extract di gu pi, Selectively Inhibit Platelet Function.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Adaptation of a cardiovascular quality improvement initiative for worksite health centers: application of the ADAPT-ITT framework.Implementation science communications · 2026Article
- Metformin-Enhanced Digital Therapeutics for the Affordable Primary Prevention of Diabetes and Cardiovascular Diseases: Advancing Low-Cost Solutions for Lifestyle-Related Chronic Disorders.Healthcare (Basel, Switzerland) · 2025Article
- Global Epidemiological Transition of Atrial Fibrillation/Flutter (1990-2021): Multidimensional Burden Dynamics and Socioeconomic Health Gradients Across 204 Countries and Territories.Reviews in cardiovascular medicine · 2025Article
- Cellular and molecular mechanisms underlying cardiovascular aging.Cellular & molecular biology letters · 2025Review
- Implementing remote patient monitoring to improve hypertension control in a primary care network: Rationale and design of the monitor-BP Cluster Randomized Trial.American heart journal · 2025Article
- Aortic arch calcification in relation to cigarette smoking: results from the multi-ethnic study of atherosclerosis (MESA).The international journal of cardiovascular imaging · 2025Article
- Cost-Effectiveness and Cost-Utility Analysis of Tongxinluo Capsules Compared With Conventional Therapy for the Treatment of Acute Myocardial Infarction.Journal of evidence-based medicine · 2025Article
- Assessing Daily Antihypertensive Medication Compliance Among Black Adults Using Smartphone-Based Ecological Momentary Assessment: A Feasibility Study.Computers, informatics, nursing : CIN · 2025Article
- The Effect of Nurse-Led Intervention on Limiting Health Costs of Cardiovascular Diseases in Chinese Adults.Journal of prevention (2022) · 2025Article
21 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundSpending on cardiovascular disease and cardiovascular risk factors (cardiovascular spending) accounts for a significant portion of overall US health care spending. Our objective was to describe US adult cardiovascular spending patterns in 2016, changes from 1996 to 2016, and factors associated with changes over time.
methodsWe extracted information on adult cardiovascular spending from the Institute for Health Metrics and Evaluation's disease expenditure project, which combines data on insurance claims, emergency department and ambulatory care visits, inpatient and nursing care facility stays, and drug prescriptions to estimate >85% of all US health care spending. Cardiovascular spending (2016 US dollars) was stratified by age, sex, type of care, payer, and cardiovascular cause. Time trend and decomposition analyses quantified contributions of epidemiology, service price and intensity (spending per unit of utilization, eg, spending per inpatient bed-day), and population growth and aging to the increase in cardiovascular spending from 1996 to 2016.
resultsAdult cardiovascular spending increased from $212 billion in 1996 to $320 billion in 2016, a period when the US population increased by >52 million people, and median age increased from 33.2 to 36.9 years. Over this period, public insurance was responsible for the majority of cardiovascular spending (54%), followed by private insurance (37%) and out-of-pocket spending (9%). Health services for ischemic heart disease ($80 billion) and hypertension ($71 billion) led to the most spending in 2016. Increased spending between 1996 and 2016 was primarily driven by treatment of hypertension, hyperlipidemia, and atrial fibrillation/flutter, for which spending rose by $42 billion, $18 billion, and $16 billion, respectively. Increasing service price and intensity alone were associated with a 51%, or $88 billion, cardiovascular spending increase from 1996 to 2016, whereas changes in disease prevalence were associated with a 37%, or $36 billion, spending reduction over the same period, after taking into account population growth and population aging.
conclusionsUS adult cardiovascular spending increased by >$100 billion from 1996 to 2016. Policies tailored to control service price and intensity and preferentially reimburse higher quality care could help counteract future spending increases caused by population aging and growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.