Evidence map›Paper›PMID 33926148›Full record

ArticleInternational journal of molecular sciences2021

A Germline-Encoded Structural Arginine Trap Underlies the Anti-DNA Reactivity of a Murine V Gene Segment.

Ronny Petterson Dos Santos Araújo, Renato Kaylan Alves França, Napoleão Fonseca Valadares, Andrea Queiroz Maranhão, Marcelo Macedo Brigido

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ronny Petterson Dos Santos AraújoDepartment of Cellular Biology, Institute of Biology, University of Brasilia, Brasilia 70910-900, Brazil.
Renato Kaylan Alves FrançaDepartment of Cellular Biology, Institute of Biology, University of Brasilia, Brasilia 70910-900, Brazil.
Napoleão Fonseca ValadaresDepartment of Cellular Biology, Institute of Biology, University of Brasilia, Brasilia 70910-900, Brazil.ORCID 0000-0002-6251-7342
Andrea Queiroz MaranhãoDepartment of Cellular Biology, Institute of Biology, University of Brasilia, Brasilia 70910-900, Brazil.ORCID 0000-0002-1946-7191
Marcelo Macedo BrigidoDepartment of Cellular Biology, Institute of Biology, University of Brasilia, Brasilia 70910-900, Brazil.ORCID 0000-0002-7136-7059
Universidade de Brasília · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autoimmunity may have its origins of early repertoire selection in developmental B cells. Such a primary repertoire is probably shaped by selecting B cells that can efficiently perform productive signaling, stimulated by self-antigens in the bone marrow, such as DNA. In support of that idea, we previously found a V segment from V

Indexed as

Amino Acid SequenceAnimalsAntibodies, AntinuclearArginineAutoantigensAutoimmunityBase SequenceDNAGerm CellsHumansImmunoglobulin Heavy ChainsImmunoglobulin Variable RegionMiceSingle-Domain AntibodiesStructure-Activity RelationshipAntibodies, AntinuclearArginineAutoantigensDNAImmunoglobulin Heavy ChainsImmunoglobulin Variable RegionSingle-Domain Antibodiesanti-DNAautoreactivityB cell’s repertoirepre-BCRV genes

Identifiers

PMID33926148
PMCPMC8123574
OpenAlexW3157180363

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.