Evidence map›Paper›PMID 33926127›Full record

ArticleMicromachines2021

Glioma-on-a-Chip Models.

Merve Ustun, Sajjad Rahmani Dabbagh, Irem Sultan Ilci, Tugba Bagci-Onder, Savas Tasoglu

Open access · goldAbstract read
In one paragraph

Article in Micromachines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Merve UstunGraduate School of Sciences and Engineering, Koc University, Sariyer, 34450 Istanbul, Turkey.ORCID 0000-0002-3883-4065
Sajjad Rahmani DabbaghDepartment of Mechanical Engineering, Koç University, Sariyer, 34450 Istanbul, Turkey.ORCID 0000-0001-8888-6106
Irem Sultan IlciDepartment of Bioengineering, Yildiz Technical University, 34220 Istanbul, Turkey.
Tugba Bagci-OnderBrain Cancer Research and Therapy Lab, Koç University School of Medicine, 34450 Istanbul, Turkey.
Savas TasogluDepartment of Mechanical Engineering, Koç University, Sariyer, 34450 Istanbul, Turkey.ORCID 0000-0003-4604-217X
Koç University · TRYıldız Technical University · TR

Funding

Alexander von Humboldt-Stiftung Research Fellowship for Experienced ResearchersHorizon 2020 Marie Skłodowska-Curie Individual Fellowship (101003361)
6 · The paper itself

Abstract

Glioma, as an aggressive type of cancer, accounts for virtually 80% of malignant brain tumors. Despite advances in therapeutic approaches, the long-term survival of glioma patients is poor (it is usually fatal within 12-14 months). Glioma-on-chip platforms, with continuous perfusion, mimic in vivo metabolic functions of cancer cells for analytical purposes. This offers an unprecedented opportunity for understanding the underlying reasons that arise glioma, determining the most effective radiotherapy approach, testing different drug combinations, and screening conceivable side effects of drugs on other organs. Glioma-on-chip technologies can ultimately enhance the efficacy of treatments, promote the survival rate of patients, and pave a path for personalized medicine. In this perspective paper, we briefly review the latest developments of glioma-on-chip technologies, such as therapy applications, drug screening, and cell behavior studies, and discuss the current challenges as well as future research directions in this field.

Indexed as

braindisease-on-a-chipgliomaorgan-on-a-chiptissue-on-a-chiptumor-on-a-chip

Identifiers

PMID33926127
PMCPMC8145995
OpenAlexW3158384526

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.