Evidence map›Paper›PMID 33926120›Full record

ArticleInternational journal of molecular sciences2021

Small-Molecule Inhibitors of the RNA M6A Demethylases FTO Potently Support the Survival of Dopamine Neurons.

Simona Selberg, Li-Ying Yu, Olesja Bondarenko, Esko Kankuri, Neinar Seli, Vera Kovaleva, Koit Herodes, Mart Saarma, Mati Karelson

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 42 citations in OpenAlex.

  1. Review
  2. mExperimental and therapeutic medicine · 2026
    Review
  3. Review
  4. The Role of NMedComm · 2026
    Review
  5. Article
  6. Article
  7. The mCells · 2025
    Review
  8. Decoding the role of mNeurochemistry international · 2025
    Review
  9. Fto-mediated mJournal of biomedical science · 2025
    Article
  10. N6-methyladenosine methylation: a novel key to unlocking mental disorders.The international journal of neuropsychopharmacology · 2025
    Review
  11. Article
  12. MiR-27a-3p protects against NaAsOScientific reports · 2025
    Article
  13. The Role ofBiomolecules · 2025
    Review
  14. Epigenetics-targeted drugs: current paradigms and future challenges.Signal transduction and targeted therapy · 2024
    Review
  15. RNA mActa neuropsychiatrica · 2024
    Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Simona SelbergInstitute of Chemistry, University of Tartu, Ravila 14a, 50411 Tartu, Estonia.
Li-Ying YuInstitute of Biotechnology, HiLIFE, Viikinkaari 5D, University of Helsinki, 00014 Helsinki, Finland.
Olesja BondarenkoInstitute of Biotechnology, HiLIFE, Viikinkaari 5D, University of Helsinki, 00014 Helsinki, Finland.ORCID 0000-0001-8767-1365
Esko KankuriDepartment of Pharmacology, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.ORCID 0000-0002-2193-8773
Neinar SeliChemestmed, Ltd., 50411 Tartu, Estonia.
Vera KovalevaInstitute of Biotechnology, HiLIFE, Viikinkaari 5D, University of Helsinki, 00014 Helsinki, Finland.
Koit HerodesInstitute of Chemistry, University of Tartu, Ravila 14a, 50411 Tartu, Estonia.
Mart SaarmaInstitute of Biotechnology, HiLIFE, Viikinkaari 5D, University of Helsinki, 00014 Helsinki, Finland.
Mati KarelsonInstitute of Chemistry, University of Tartu, Ravila 14a, 50411 Tartu, Estonia.
University of Helsinki · FIUniversity of Tartu · EE

Funding

Chemestmed, Ltd. 11-18/IK/90
6 · The paper itself

Abstract

The fat mass and obesity-associated protein (FTO), an RNA N

Indexed as

AdenosineAlpha-Ketoglutarate-Dependent Dioxygenase FTOAnimalsAnimals, Outbred StrainsApoptosisDemethylationDopaminergic NeuronsDrug DesignMethyltransferasesMiceMolecular Docking SimulationPrimary Cell CultureRNA6-methyladenine mRNA methyltransferaseAdenosineAlpha-Ketoglutarate-Dependent Dioxygenase FTOFTO protein, mouseMethyltransferasesRNAALKBH5dopamine neuronsdrug designFTOm6ARNA

Identifiers

PMID33926120
PMCPMC8123663
OpenAlexW3158384021

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.