Evidence map›Paper›PMID 33926045›Full record

ArticleBiomolecules2021

Moderating Effects of BDNF Genetic Variants and Smoking on Cognition in PTSD Veterans.

Gordana Nedic Erjavec, Matea Nikolac Perkovic, Lucija Tudor, Suzana Uzun, Zrnka Kovacic Petrovic, Marcela Konjevod, Marina Sagud, Oliver Kozumplik, Dubravka Svob Strac, Tina Peraica and 4 more

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. International journal of molecular sciences · 2025
    Article
  3. Review
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 1 country.

Gordana Nedic ErjavecLaboratory for Molecular Neuropsychiatry, Division of Molecular Medicine, Rudjer Boskovic Institute, 10000 Zagreb, Croatia.ORCID 0000-0002-0787-9340
Matea Nikolac PerkovicLaboratory for Molecular Neuropsychiatry, Division of Molecular Medicine, Rudjer Boskovic Institute, 10000 Zagreb, Croatia.ORCID 0000-0002-3113-0778
Lucija TudorLaboratory for Molecular Neuropsychiatry, Division of Molecular Medicine, Rudjer Boskovic Institute, 10000 Zagreb, Croatia.
Suzana UzunDepartment for Biological Psychiatry and Psychogeriatrics, University Psychiatric Hospital Vrapce, 10090 Zagreb, Croatia.
Zrnka Kovacic PetrovicDepartment for Biological Psychiatry and Psychogeriatrics, University Psychiatric Hospital Vrapce, 10090 Zagreb, Croatia.
Marcela KonjevodLaboratory for Molecular Neuropsychiatry, Division of Molecular Medicine, Rudjer Boskovic Institute, 10000 Zagreb, Croatia.
Marina SagudSchool of Medicine, The University of Zagreb, 10000 Zagreb, Croatia.ORCID 0000-0001-9620-2181
Oliver KozumplikDepartment for Biological Psychiatry and Psychogeriatrics, University Psychiatric Hospital Vrapce, 10090 Zagreb, Croatia.
Dubravka Svob StracLaboratory for Molecular Neuropsychiatry, Division of Molecular Medicine, Rudjer Boskovic Institute, 10000 Zagreb, Croatia.ORCID 0000-0001-6200-2405
Tina PeraicaDepartment of Psychiatry, University Hospital Dubrava, 10000 Zagreb, Croatia.ORCID 0000-0001-7098-3282
Ninoslav MimicaDepartment for Biological Psychiatry and Psychogeriatrics, University Psychiatric Hospital Vrapce, 10090 Zagreb, Croatia.ORCID 0000-0003-4552-0547
Ana Havelka MestrovicRochester Institute of Technology Croatia, 10000 Zagreb, Croatia.
Denis ZilicAXON LAB d.o.o., 10000 Zagreb, Croatia.
Nela PivacLaboratory for Molecular Neuropsychiatry, Division of Molecular Medicine, Rudjer Boskovic Institute, 10000 Zagreb, Croatia.
Ruđer Bošković Institute · HRUniversity of Osijek · HRUniversity of Zagreb · HROikon (Croatia) · HRRochester Institute of Technology Croatia · HRUniversity Hospital Centre Zagreb · HRUniversity Hospital Dubrava · HR

Funding

Hrvatska akademija znanosti i umjetnosti /Croatian Academy of Sciences and Arts 1452H05
6 · The paper itself

Abstract

Posttraumatic stress disorder (PTSD) is frequently associated with cognitive disturbances and high prevalence of smoking. This study evaluated cognition in war veterans with PTSD and control subjects, controlled for the effect of smoking and brain derived neurotrophic factor (BDNF) rs6265 and rs56164415 genotypes/alleles. Study included 643 male war veterans with combat related PTSD and 120 healthy controls. Genotyping was done by real time PCR. Cognitive disturbances were evaluated using the Positive and Negative Syndrome Scale (PANSS) cognition subscale and the Rey-Osterrieth Complex Figure (ROCF) test scores. Diagnosis (

Indexed as

AgedBrain-Derived Neurotrophic FactorCognitionCognitive DysfunctionGene FrequencyGenotypeHumansMaleMiddle AgedPolymorphism, Single NucleotideSmokingStress Disorders, Post-TraumaticVeteransBDNF protein, humanBrain-Derived Neurotrophic FactorBDNF rs56164415BDNF rs6265cognitionPTSDsmokingwar veterans

Identifiers

PMID33926045
PMCPMC8146493
OpenAlexW3159824321

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.