Evidence map›Paper›PMID 33925917›Full record

ArticleAntioxidants (Basel, Switzerland)2021

Analysis and Optimization of Conditions for the Use of 2',7'-Dichlorofluorescein Diacetate in Cultured Hepatocytes.

Megan J Reiniers, Lianne R de Haan, Laurens F Reeskamp, Mans Broekgaarden, Rowan F van Golen, Michal Heger

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Assessment of the Biological Properties ofMolecules (Basel, Switzerland) · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. On the Photo-Eradication of Methicillin-ResistantInternational journal of molecular sciences · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 3 countries.

Megan J ReiniersJiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics, Department of Pharmaceutics, College of Medicine, Jiaxing University, Jiaxing 314001, China.ORCID 0000-0002-7905-2676
Lianne R de HaanJiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics, Department of Pharmaceutics, College of Medicine, Jiaxing University, Jiaxing 314001, China.
Laurens F ReeskampDepartment of Vascular Medicine, Amsterdam UMC, Location AMC, 1105 AZ Amsterdam, The Netherlands.
Mans BroekgaardenTeam Cancer Targets and Experimental Therapeutics, Department Microenvironment Cell Plasticity and Signaling, Institute for Advanced Biosciences, CNRS UMR 5309, Université de Grenoble-Alpes, Allée des Alpes, 38700 La Tronche, France.ORCID 0000-0002-9516-5048
Rowan F van GolenDepartment of Gastroenterology and Hepatology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Michal HegerJiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics, Department of Pharmaceutics, College of Medicine, Jiaxing University, Jiaxing 314001, China.ORCID 0000-0002-0630-4465
Amsterdam University Medical Centers · NLCentre National de la Recherche Scientifique · FRErasmus MC · NLJiaxing University · CNLeiden University Medical Center · NLUtrecht University · NL

Funding

grant for the establishment of the Jiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics 2019.12KWF Kankerbestrijding 10666Zhejiang Provincial Foreign Expert Program Grant 2019.12Zhejiang Provincial Key Natural Science Foundation of China #Z20H160031
6 · The paper itself

Abstract

Numerous liver pathologies encompass oxidative stress as molecular basis of disease. The use of 2',7'-dichlorodihydrofluorescein-diacetate (DCFH

Indexed as

anoxia and reoxygenationcellular uptake and exportfluorogenic redox probehepatocytesintravital fluorescence imagingliver diseasesoxidative and nitrosative stress

Identifiers

PMID33925917
PMCPMC8147027
OpenAlexW3157130467

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.