Evidence map›Paper›PMID 33925787›Full record

ArticleInternational journal of molecular sciences2021

Hydrocephalus Following Experimental Subarachnoid Hemorrhage in Rats with Different Aerobic Capacity.

Yasunori Toyota, Hajime Shishido, Fenghui Ye, Lauren G Koch, Steven L Britton, Hugh J L Garton, Richard F Keep, Guohua Xi, Ya Hua

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Molecular Mechanisms of Cerebrovascular Diseases.International journal of molecular sciences · 2022
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yasunori ToyotaDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA.
Hajime ShishidoDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA.
Fenghui YeDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA.
Lauren G KochDepartment of Physiology & Pharmacology, University of Toledo College of Medicine & Life Sciences, Toledo, OH 43614, USA.
Steven L BrittonDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI 48109, USA.
Hugh J L GartonDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA.
Richard F KeepDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA.
Guohua XiDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA.
Ya HuaDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA.
University of Michigan · USUniversity of Toledo · US

Funding

Experimental Cerebral Hemorrhage: Mechanisms and TherapiesR35NS116786 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XI, GUOHUA · 2020 to 2024
$5.2M
Early hematoma lysis and hemoglobin toxicity in intracerebral hemorrhageR01NS106746 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KEEP, RICHARD F · 2018 to 2022
$2.5M
Resource for Rat Genetic Models of Aerobic CapacityP40OD021331 · OD · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI KOCH, LAUREN GERARD · 2015 to 2019
$1.9M
NIH HHS P40 OD021331NINDS NIH HHS NS116786NINDS NIH HHS R01 NS106746NINDS NIH HHS R35 NS116786
6 · The paper itself

Abstract

Low aerobic capacity is considered to be a risk factor for stroke, while the mechanisms underlying the phenomenon are still unclear. The current study looked into the impacts of different aerobic capacities on early brain injury in a subarachnoid hemorrhage (SAH) model using rats bred for high and low aerobic capacity (high-capacity runners, HCR; low-capacity runners, LCR). SAH was modeled with endovascular perforation in HCR and LCR rats. Twenty-four hours after SAH, the rats underwent behavioral testing and MRI, and were then euthanized. The brains were used to investigate ventricular wall damage, blood-brain barrier breakdown, oxidative stress, and hemoglobin scavenging. The LCR rats had worse SAH grades (

Indexed as

Oxidative StressAnimalsAntigens, CDAntigens, Differentiation, MyelomonocyticBrainCD163 AntigenDisease Models, AnimalHeme Oxygenase-1HydrocephalusMagnetic Resonance ImagingRatsReceptors, Cell SurfaceRunningStrokeSubarachnoid HemorrhageAntigens, CDAntigens, Differentiation, MyelomonocyticCD163 AntigenHeme Oxygenase-1Receptors, Cell SurfaceCD163early brain injuryhemeoxgenase-1hydrocephalusratsubarachnoid hemorrhage

Identifiers

PMID33925787
PMCPMC8123480
OpenAlexW3158730837

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.