Evidence map›Paper›PMID 33925769›Full record

ArticleMicromachines2021

Microsphere-Based Microfluidic Device for Plasma Separation and Potential Biochemistry Analysis Applications.

Hongyan Xu, Zhangying Wu, Jinan Deng, Jun Qiu, Ning Hu, Lihong Gao, Jun Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Micromachines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Hongyan XuKey Laboratory of Biorheological Science and Technology, Ministry of Education and Bioengineering College, Chongqing University, Chongqing 400030, China.
Zhangying WuKey Laboratory of Biorheological Science and Technology, Ministry of Education and Bioengineering College, Chongqing University, Chongqing 400030, China.
Jinan DengKey Laboratory of Biorheological Science and Technology, Ministry of Education and Bioengineering College, Chongqing University, Chongqing 400030, China.
Jun QiuDepartment of Information, First Affiliated Hospital, Army Medical University, Chongqing 400042, China.
Ning HuKey Laboratory of Biorheological Science and Technology, Ministry of Education and Bioengineering College, Chongqing University, Chongqing 400030, China.ORCID 0000-0002-6902-3302
Lihong GaoChongqing Center for Drug Evaluation and Certification, Chongqing 401120, China.
Jun YangKey Laboratory of Biorheological Science and Technology, Ministry of Education and Bioengineering College, Chongqing University, Chongqing 400030, China.ORCID 0000-0001-6877-8677
Chongqing University · CNArmy Medical University · CN

Funding

Fundamental Research Funds for the Central Universities 2020CDJQY-A058, 2020CDJ-LHZZ-031National Natural Science Foundation of China 21827812, 81871450Natural Science Foundation of Chongqing, China cstc2020jcyj-msxmX0680, cstc2019jcyj-bshX0006
6 · The paper itself

Abstract

The development of a simple, portable, and cost-effective plasma separation platform for blood biochemical analysis is of great interest in clinical diagnostics. We represent a plasma separation microfluidic device using microspheres with different sizes as the separation barrier. This plasma separation device, with 18 capillary microchannels, can extract about 3 μL of plasma from a 50 μL blood sample in about 55 min. The effects of evaporation and the microsphere barrier on the plasma biochemical analysis results were studied. Correction factors were applied to compensate for these two effects. The feasibility of the device in plasma biochemical analysis was validated with clinical blood samples.

Indexed as

concentration detectionmicrochipmicrospheres stackingplasma separation

Identifiers

PMID33925769
PMCPMC8144965
OpenAlexW3159763564

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.