Evidence map›Paper›PMID 33925683›Full record

ArticleCancers2021

The Lymph-Sparing Quotient: A Retrospective Risk Analysis on Extremity Radiation for Soft Tissue Sarcoma Treatment.

Iqbal Sarif, Khaled Elsayad, Daniel Rolf, Christopher Kittel, Georg Gosheger, Eva Wardelmann, Uwe Haverkamp, Hans Theodor Eich

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. FLASH proton reirradiation, with or without hypofractionation, reduces chronic toxicity in the normal murine intestine, skin, and bone.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Iqbal SarifDepartment of Radiation Oncology, University Hospital Muenster, 48149 Munster, Germany.
Khaled ElsayadDepartment of Radiation Oncology, University Hospital Muenster, 48149 Munster, Germany.ORCID 0000-0001-9303-7336
Daniel RolfDepartment of Radiation Oncology, University Hospital Muenster, 48149 Munster, Germany.
Christopher KittelDepartment of Radiation Oncology, University Hospital Muenster, 48149 Munster, Germany.
Georg GoshegerDepartment of Orthopedics and Tumor Orthopedics, University Hospital Muenster, 48149 Muenster, Germany.
Eva WardelmannGerhard Domagk Institute of Pathology, University Hospital Muenster, 48149 Muenster, Germany.
Uwe HaverkampDepartment of Radiation Oncology, University Hospital Muenster, 48149 Munster, Germany.
Hans Theodor EichDepartment of Radiation Oncology, University Hospital Muenster, 48149 Munster, Germany.
University Hospital Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiation therapy (RT) for extremity soft tissue sarcoma is associated with lymphedema risk. In this study, we analyzed the influence of lymph-sparing volume on the lymphedema occurrence in patients who received adjuvant extremity RT. The lymph-sparing quotient (LSQ) was calculated by dividing the lymph-sparing volume by the total extremity volume with double weightingfor the narrowest lymph-sparing region. A total of 34 patients were enrolled in this analysis. The median applied total radiation dose was 66.3 Gy in 36 fractions. Acute lymphedema appeared in 12 patients (35%). Most of them (

Indexed as

lymphedemapersonalized treatmentradiotherapyrisk-based treatmentsoft tissue sarcomatoxicity

Identifiers

PMID33925683
PMCPMC8125651
OpenAlexW3157565980

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.