Evidence map›Paper›PMID 33925556›Full record

ArticleNutrients2021

Longitudinal Changes in the Concentration of Major Human Milk Proteins in the First Six Months of Lactation and Their Effects on Infant Growth.

Jian Zhang, Ai Zhao, Shiyun Lai, Qingbin Yuan, Xiaojiang Jia, Peiyu Wang, Yumei Zhang

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Osteopontin: Its Properties, Recent Studies, and Potential Applications.International journal of molecular sciences · 2025
    Review
  8. Macronutrient concentrations in human milk beyond the first half year of lactation: a cohort study.Archives of disease in childhood. Fetal and neonatal edition · 2025
    Article
  9. [Mammary epithelial cells from women synthetize omega-3 and 6 fatty acids].Revista medica del Instituto Mexicano del Seguro Social · 2025
    Observational
  10. Review
  11. Article
  12. Article
  13. Article
  14. Antimicrobial Properties of Colostrum and Milk.Antibiotics (Basel, Switzerland) · 2024
    Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jian ZhangDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China.ORCID 0000-0001-7246-2608
Ai ZhaoVanke School of Public Health, Tsinghua University, Beijing 100091, China.
Shiyun LaiHangzhou Popide Sci. & Tech. Co., Ltd., Hangzhou 311112, China.
Qingbin YuanJunlebao Dairy Group, Shijiazhuang 050221, China.
Xiaojiang JiaJunlebao Dairy Group, Shijiazhuang 050221, China.
Peiyu WangDepartment of Social Medicine and Health Education, School of Public Health, Peking University, Beijing 100191, China.
Yumei ZhangDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China.ORCID 0000-0002-0103-7900
Peking University · CNVanke (China) · CN

Funding

13th Five-year Plan for National Key Research and Development Program of China 2017YFD0400602
6 · The paper itself

Abstract

Our knowledge related to human milk proteins is still limited. The present study determined the changes in multiple human milk proteins during the first six months of lactation, investigated the influencing factors of milk proteins, and explored the impact of milk proteins on infant growth. A total of 105 lactating women and their full-term infants from China were prospectively surveyed in this research. Milk samples were collected at 1-5 days, 8-14 days, 1 month, and 6 months postpartum. Concentrations of total protein and α-lactalbumin were measured in all milk samples, and concentrations of lactoferrin, osteopontin, total casein, β-casein, α

Indexed as

Body WeightBreast FeedingFemaleHumansInfantInfant, NewbornLactationLongitudinal StudiesMaleMilk, HumanMilk ProteinsMilk Proteinscaseinhuman milkinfant growthlactoferrinosteopontinproteinα-lactalbumin

Identifiers

PMID33925556
PMCPMC8147063
OpenAlexW3194949000

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.