Evidence map›Paper›PMID 33925438›Full record

ArticleHealthcare (Basel, Switzerland)2021

Regulatory Role of Orexin in the Antistress Effect of "Press Tack Needle" Acupuncture Treatment.

Aki Fujiwara, Mana Tsukada, Hideshi Ikemoto, Takuji Izuno, Satoshi Hattori, Takayuki Okumo, Tadashi Hisamitsu, Masataka Sunagawa

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Healthcare (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Aki FujiwaraDepartment of Physiology, School of Medicine, Showa University, Tokyo 142-8555, Japan.
Mana TsukadaDepartment of Physiology, School of Medicine, Showa University, Tokyo 142-8555, Japan.
Hideshi IkemotoDepartment of Physiology, School of Medicine, Showa University, Tokyo 142-8555, Japan.ORCID 0000-0002-7912-8984
Takuji IzunoDepartment of Physiology, School of Medicine, Showa University, Tokyo 142-8555, Japan.
Satoshi HattoriDepartment of Physiology, School of Medicine, Showa University, Tokyo 142-8555, Japan.
Takayuki OkumoDepartment of Physiology, School of Medicine, Showa University, Tokyo 142-8555, Japan.ORCID 0000-0003-4633-6506
Tadashi HisamitsuDepartment of Physiology, School of Medicine, Showa University, Tokyo 142-8555, Japan.ORCID 0000-0002-2506-2844
Masataka SunagawaDepartment of Physiology, School of Medicine, Showa University, Tokyo 142-8555, Japan.ORCID 0000-0001-7621-2024
Showa University · JP

Funding

Japan Society for the Promotion of Science 17K09325
6 · The paper itself

Abstract

The aim of this research was to investigate the antistress effect of press tack needle (PTN) acupuncture treatment using rats with social isolation stress (SIS). Rats were divided into non-stress group (Grouped+sham), stress group (SIS+sham), and PTN-treated SIS group (SIS+PTN). Rats in the SIS+PTN and SIS+sham groups were housed alone for eight days. For the SIS+PTN group, a PTN (length, 0.3 or 1.2 mm) was fixed on the GV20 acupoint on day 7. We measured stress behavior based on the time the rats showed aggressive behavior and the levels of plasma corticosterone and orexin A on day 8. In addition, the orexin-1 receptor or orexin-2 receptor antagonist was administered to rats that were exposed to SIS. The duration of aggressive behavior was significantly prolonged in the SIS+sham group, and the prolonged duration was inhibited in the SIS+PTN (1.2 mm) group. The levels of plasma corticosterone and orexin A were significantly increased in the SIS+sham group; however, these increases were inhibited in the SIS+PTN group. The aggressive behavior was significantly reduced after the orexin-2 receptor antagonist was administered. These findings suggest that PTN treatment at GV20 may have an antistress effect, and the control of orexin is a mechanism underlying this phenomenon.

Indexed as

acupunctureaggressive behaviorantistress effectorexinorexin receptorpress tack needle

Identifiers

PMID33925438
PMCPMC8146164
OpenAlexW3157716413

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.