Evidence map›Paper›PMID 33925369›Full record

ArticleInternational journal of environmental research and public health2021

Development and Validation of a Sensitive, Specific and Reproducible UPLC-MS/MS Method for the Quantification of OJT007, A Novel Anti-Leishmanial Agent: Application to a Pharmacokinetic Study.

Maria Rincon Nigro, Jing Ma, Ololade Tosin Awosemo, Huan Xie, Omonike Arike Olaleye, Dong Liang

Open access · goldAbstract read
In one paragraph

Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. The effect of pH stability and aqueous solubility on the oral bioavailability of a novel antileishmanial agent.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Maria Rincon NigroDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004, USA.
Jing MaDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004, USA.ORCID 0000-0002-9233-0247
Ololade Tosin AwosemoDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004, USA.
Huan XieDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004, USA.ORCID 0000-0002-0591-5619
Omonike Arike OlaleyeDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004, USA.
Dong LiangDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004, USA.ORCID 0000-0001-6632-8066
Texas Southern University · USBristol-Myers Squibb (United States) · US

Funding

Targeted Nano-drug-delivery-systems of Frist-in-class Drugs for CRPC: PK/PD Evaluation and Combination TherapyU54MD007605 · NIMHD · TEXAS SOUTHERN UNIVERSITY · PI Dong Liang, Huan Xie · 2020 to 2026
$22.0M
Urgent Competitive Revision to Existing NIH Grants and Cooperative Agreements (Urgent Supplement - Clinical Trial Optional)U24MD015970 · NIMHD · MOREHOUSE SCHOOL OF MEDICINE · PI Sandra Perreira Chang, Elizabeth O. Ofili · 2020 to 2026
$20.6M
NIMHD NIH HHS U24 MD015970NIMHD NIH HHS U54MD007605
6 · The paper itself

Abstract

OJT007 is a methionine aminopeptidase 1 (MetAP1) inhibitor with potent anti-proliferative effects against

Indexed as

Tandem Mass SpectrometryAnimalsChromatography, High Pressure LiquidChromatography, LiquidRatsRats, Sprague-DawleyReproducibility of ResultsleishmaniasisOJT007pharmacokineticsratsUPLC-MS/MS

Identifiers

PMID33925369
PMCPMC8123827
OpenAlexW3159441923

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.