Evidence map›Paper›PMID 33925233›Full record

ReviewInternational journal of molecular sciences2021

Precision Oncology via NMR-Based Metabolomics: A Review on Breast Cancer.

Alessia Vignoli, Emanuela Risi, Amelia McCartney, Ilenia Migliaccio, Erica Moretti, Luca Malorni, Claudio Luchinat, Laura Biganzoli, Leonardo Tenori

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alessia VignoliMagnetic Resonance Center (CERM), University of Florence, 50019 Sesto Fiorentino, Italy.ORCID 0000-0003-4038-6596
Emanuela RisiDepartment of Medical Oncology, New Hospital of Prato S. Stefano, 59100 Prato, Italy.
Amelia McCartneyDepartment of Medical Oncology, New Hospital of Prato S. Stefano, 59100 Prato, Italy.ORCID 0000-0003-0411-0736
Ilenia MigliaccioDepartment of Medical Oncology, New Hospital of Prato S. Stefano, 59100 Prato, Italy.
Erica MorettiDepartment of Medical Oncology, New Hospital of Prato S. Stefano, 59100 Prato, Italy.
Luca MalorniDepartment of Medical Oncology, New Hospital of Prato S. Stefano, 59100 Prato, Italy.ORCID 0000-0002-4297-2997
Claudio LuchinatMagnetic Resonance Center (CERM), University of Florence, 50019 Sesto Fiorentino, Italy.
Laura BiganzoliDepartment of Medical Oncology, New Hospital of Prato S. Stefano, 59100 Prato, Italy.
Leonardo TenoriMagnetic Resonance Center (CERM), University of Florence, 50019 Sesto Fiorentino, Italy.ORCID 0000-0001-6438-059X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Precision oncology is an emerging approach in cancer care. It aims at selecting the optimal therapy for the right patient by considering each patient's unique disease and individual health status. In the last years, it has become evident that breast cancer is an extremely heterogeneous disease, and therefore, patients need to be appropriately stratified to maximize survival and quality of life. Gene-expression tools have already positively assisted clinical decision making by estimating the risk of recurrence and the potential benefit from adjuvant chemotherapy. However, these approaches need refinement to further reduce the proportion of patients potentially exposed to unnecessary chemotherapy. Nuclear magnetic resonance (NMR) metabolomics has demonstrated to be an optimal approach for cancer research and has provided significant results in BC, in particular for prognostic and stratification purposes. In this review, we give an update on the status of NMR-based metabolomic studies for the biochemical characterization and stratification of breast cancer patients using different biospecimens (breast tissue, blood serum/plasma, and urine).

Indexed as

Breast NeoplasmsFemaleHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMedical OncologyMetabolomicsNeoplasm Recurrence, LocalPrecision MedicinePrognosisbreast cancerchemotherapymetabolomicsNMRprecision medicine

Identifiers

PMID33925233
PMCPMC8124948

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.