Evidence map›Paper›PMID 33925089›Full record

ArticleInternational journal of molecular sciences2021

Broadly Antiviral Activities of TAP1 through Activating the TBK1-IRF3-Mediated Type I Interferon Production.

Jin Zhao, Ruiting Li, Yanjun Li, Jiaoshan Chen, Fengling Feng, Caijun Sun

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jin ZhaoSchool of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou 514400, China.ORCID 0000-0003-0797-6404
Ruiting LiSchool of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou 514400, China.
Yanjun LiSchool of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou 514400, China.
Jiaoshan ChenSchool of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou 514400, China.
Fengling FengSchool of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou 514400, China.
Caijun SunSchool of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou 514400, China.ORCID 0000-0002-2000-7053
Sun Yat-sen University · CN

Funding

China Postdoctoral Science Foundation 2020T130150ZXNational Natural Science Foundation of China 81971927Natural Science Foundation of Guangdong Province 2019A1515110458Science and Technology Planning Project of Shenzhen City 20190804095916056, JSGG20200225152008136, JCYJ20200109142601702
6 · The paper itself

Abstract

Deeply understanding the virus-host interaction is a prerequisite for developing effective anti-viral strategies. Traditionally, the transporter associated with antigen processing type 1 (TAP1) is critical for antigen presentation to regulate adaptive immunity. However, its role in controlling viral infections through modulating innate immune signaling is not yet fully understood. In the present study, we reported that

Indexed as

AnimalsAntiviral AgentsATP Binding Cassette Transporter, Subfamily B, Member 2Gene Knockout TechniquesHEK293 CellsHost Microbial InteractionsHumansImmunity, InnateInterferon Regulatory Factor-3Interferon Type IMiceModels, ImmunologicalProtein Serine-Threonine KinasesRAW 264.7 CellsToll-Like ReceptorsVirus DiseasesAntiviral AgentsATP Binding Cassette Transporter, Subfamily B, Member 2Interferon Regulatory Factor-3Interferon Type IIRF3 protein, humanProtein Serine-Threonine KinasesTAP1 protein, humanTap1 protein, mouseTBK1 protein, humanToll-Like Receptorsbroadly antiviral activityinnate immunityinterferon-stimulated genes (ISGs)transporter associated with antigen processing 1 (TAP1)type I interferons (IFN-Is)

Identifiers

PMID33925089
PMCPMC8125511
OpenAlexW3157432015

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.